Molecular structure of Flutax 1, CAS Number: 191930-58-2
Flutax 1 (CAS 191930-58-2)
See product citations (2)
Alternate Names:
7-O-[N-(4Fluoresceincarbonyl)-L-alanyl]Taxol
Application:
Flutax 1 is a fluorescent taxol derivative
CAS Number:
191930-58-2
Purity:
≥98%
Molecular Weight:
1283.28
Molecular Formula:
C71H66N2O21
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Flutax 1 is a fluorescent taxol (sc-201439) derivative that binds to the taxol microtubule binding site with high affinity (Ka ~ 107M-1). This chemical is useful for direct imaging of the microtubule cytoskeleton. This compound, known as Flutax 1 is a valuable compound for research purposes. It has a molecular formula of C71H66N2O21 and a molecular weight of 1283.3. Typically, its purity stands at 95%.
Flutax 1 (CAS 191930-58-2) References
- Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site. | Díaz, JF., et al. 2000. J Biol Chem. 275: 26265-76. PMID: 10818101
- Fast kinetics of Taxol binding to microtubules. Effects of solution variables and microtubule-associated proteins. | Díaz, JF., et al. 2003. J Biol Chem. 278: 8407-19. PMID: 12496245
- Comparison of the binding of anti-tubulin antibody and the fluorescent taxol derivative Flutax-1 to the microtubular system of Tetrahymena. | Kovács, P. and Csaba, G. 2006. Acta Biol Hung. 57: 323-9. PMID: 17048696
- The use of an occlusion perfusion catheter to deliver paclitaxel to the arterial wall. | Atigh, MK., et al. 2017. Cardiovasc Ther. 35: PMID: 28445625
- Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1). | Sajid, A., et al. 2018. PLoS One. 13: e0204693. PMID: 30265721
- Identification of a lathyrane-type diterpenoid EM-E-11-4 as a novel paclitaxel resistance reversing agent with multiple mechanisms of action. | Liu, Q., et al. 2020. Aging (Albany NY). 12: 3713-3729. PMID: 32108588
- Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity. | Zhang, D. and Kanakkanthara, A. 2020. Cancers (Basel). 12: PMID: 32610496
- ATIP3 deficiency facilitates intracellular accumulation of paclitaxel to reduce cancer cell migration and lymph node metastasis in breast cancer patients. | Rodrigues-Ferreira, S., et al. 2020. Sci Rep. 10: 13217. PMID: 32764625
- Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein. | Sajid, A., et al. 2020. Proc Natl Acad Sci U S A. 117: 29609-29617. PMID: 33168729
- Blinking Fluorescent Probes for Tubulin Nanoscopy in Living and Fixed Cells. | Gerasimaitė, RT., et al. 2021. ACS Chem Biol. 16: 2130-2136. PMID: 34734690
- Drugs That Changed Society: Microtubule-Targeting Agents Belonging to Taxanoids, Macrolides and Non-Ribosomal Peptides. | Christensen, SB. 2022. Molecules. 27: PMID: 36080414
- Role of motor proteins in human cancers. | Hassan Ibrahim, I., et al. 2022. Saudi J Biol Sci. 29: 103436. PMID: 36131778
- Fluorescent taxoids as probes of the microtubule cytoskeleton. | Evangelio, JA., et al. 1998. Cell Motil Cytoskeleton. 39: 73-90. PMID: 9453715
Inhibitor of:
Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flutax 1, 1 mg | sc-203958 | 1 mg | $223.00 | |||
| US: Only available in the US | ||||||