Molecular structure of Flurofamide, CAS Number: 70788-28-2
Flurofamide (CAS 70788-28-2)
Alternate Names:
N-(Diaminophosphinyl)-4-fluorobenzamide
Application:
Flurofamide is an inhibitor of bacterial urease
CAS Number:
70788-28-2
Molecular Weight:
217.14
Molecular Formula:
C7H9FN3O2P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Flurofamide is a bacterial urease inhibitor with a potency 1000 fold greater than Acetohydroxamic Acid (sc-207251). The compound has been observed to reduce the infection of Cryptococcus neoforman′s transmigration in the mouse brain by urease inhibition. In a study on catheter encrustation, Flurofamide was documented, at 10 mug/ml, to reduce the pH of P. mirabilis-infected urine and the calcium and magnesium salt depositions.
Flurofamide (CAS 70788-28-2) References
- Marked reduction of Helicobacter pylori-induced gastritis by urease inhibitors, acetohydroxamic acid and flurofamide, in Mongolian gerbils. | Ohta, T., et al. 2001. Biochem Biophys Res Commun. 285: 728-33. PMID: 11453654
- Effect of the metabolism of urea on the acidifying activity of Streptococcus thermophilus. | Pernoud, S., et al. 2004. J Dairy Sci. 87: 550-5. PMID: 15202638
- Glutamine synthesis is essential for growth of Streptococcus thermophilus in milk and is linked to urea catabolism. | Monnet, C., et al. 2005. Appl Environ Microbiol. 71: 3376-8. PMID: 15933046
- Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain. | Shi, M., et al. 2010. J Clin Invest. 120: 1683-93. PMID: 20424328
- Flurofamide Prevention and Treatment of Ureaplasma-Induced Hyperammonemia. | Fleming, D. and Patel, R. 2022. Microbiol Spectr. 10: e0192722. PMID: 35993783
- Ureaplasma-urealyticum-induced bladder stones in rats and their prevention by flurofamide and doxycycline. | Texier-Maugein, J., et al. 1987. Isr J Med Sci. 23: 565-7. PMID: 3667226
- The failure of flurofamide to control ureaplasma in bovine semen. | Truscott, RB. and Brown, C. 1986. Can J Vet Res. 50: 289-90. PMID: 3756683
- Investigation into the inhibitory effect of flurofamide on animal ureaplasmas and its use in the treatment of ureaplasma-infected sheep. | Ball, HJ. and McCaughey, WJ. 1986. J Vet Pharmacol Ther. 9: 280-5. PMID: 3761418
- The inhibitory effect of flurofamide on ureaplasmas and their elimination from marmosets by its use. | Furr, PM., et al. 1984. J Antimicrob Chemother. 14: 613-8. PMID: 6440884
- Inhibition of the growth of Ureaplasma urealyticum by a new urease inhibitor, flurofamide. | Kenny, GE. 1983. Yale J Biol Med. 56: 717-22. PMID: 6679152
- Flurofamide: a potent inhibitor of bacterial urease with potential clinical utility in the treatment of infection induced urinary stones. | Millner, OE., et al. 1982. J Urol. 127: 346-50. PMID: 7038144
- The effect of urease inhibitors on the encrustation of urethral catheters. | Morris, NS. and Stickler, DJ. 1998. Urol Res. 26: 275-9. PMID: 9760002
- Helicobacter pylori containing only cytoplasmic urease is susceptible to acid. | Krishnamurthy, P., et al. 1998. Infect Immun. 66: 5060-6. PMID: 9784504
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flurofamide, 50 mg | sc-203957 | 50 mg | $167.00 |