Fluprostenol isopropyl ester CAS: 157283-68-6
MF: C26H35F3O6
MW: 500.55
A prodrug PGFR agonist.

Fluprostenol isopropyl ester (CAS 157283-68-6)

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Alternate Names: (+)-Travoprost; (±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2
Application: Fluprostenol isopropyl ester is a prodrug PGFR agonist
CAS Number: 157283-68-6
Molecular Weight: 500.55
Molecular Formula: C26H35F3O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Fluprostenol isopropyl ester is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Fluprostenol isopropyl ester is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, (+)-fluprostenol, is a potent PGFR (FP receptor) agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.


References

1. Hellberg, M.R., et al. 2001. J Ocul Pharmacol Ther. 17: 421-432. PMID: 11765147
2. Abramovitz, M., et al. 2000. Biochim Biophys Acta. 1483: 285-293. PMID: 10634944
3. Stjernschantz, J., et al. 1995. Adv. Prostaglandin Thromboxane Leukot. Res. 23: 513-518. PMID: 7732899

Formulation :
A solution in ethanol
Appearance :
A solution in ethanol
Physical State :
Liquid
Storage :
Store at -20° C
Boiling Point :
534.8-634.8° C at 760 mmHg (Predicted)
Density :
1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
pK Values :
pKa: 13.43 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6916019
MDL Number :
MFCD03411995
SMILES :
CC(C)OC(=O)CCC/C=C/C[[email protected]]1[[email protected]](C[[email protected]]([[email protected]@H]1/C=C/[[email protected]](COC2=CC=CC(=C2)C(F)(F)F)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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