Molecular structure of Fluprostenol isopropyl ester, CAS Number: 157283-68-6
Fluprostenol isopropyl ester (CAS 157283-68-6)
Alternate Names:
(+)-Travoprost; (±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2
Application:
Fluprostenol isopropyl ester is a prodrug PGF2αR agonist
CAS Number:
157283-68-6
Molecular Weight:
500.55
Molecular Formula:
C26H35F3O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Travoprost is the Alcon trade name for (+)-fluprostenol isopropyl ester, an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1,2 Travoprost is the active ingredient in Alcon′s Travatan brand ophthalmic solution. This compound is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid.3 The free acid, (+)-fluprostenol, is a potent FP receptor agonist.4 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
Fluprostenol isopropyl ester (CAS 157283-68-6) References
- The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. | Abramovitz, M., et al. 2000. Biochim Biophys Acta. 1483: 285-93. PMID: 10634944
- Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. | Hellberg, MR., et al. 2001. J Ocul Pharmacol Ther. 17: 421-32. PMID: 11765147
- Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues. | Sharif, NA., et al. 2003. Invest Ophthalmol Vis Sci. 44: 715-21. PMID: 12556403
- Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. | Thieme, H., et al. 2006. Invest Ophthalmol Vis Sci. 47: 938-45. PMID: 16505027
- Preclinical pharmacology of latanoprost, a phenyl-substituted PGF2 alpha analogue. | Stjernschantz, J., et al. 1995. Adv Prostaglandin Thromboxane Leukot Res. 23: 513-8. PMID: 7732899
Activator of:
DP, and PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluprostenol isopropyl ester, 1 mg | sc-205327 | 1 mg | $80.00 | |||
Fluprostenol isopropyl ester, 5 mg | sc-205327A | 5 mg | $465.00 |