Fluprostenol-d4
Alternate Names:
F2&slpha;-d4
Molecular Weight:
462.49
Molecular Formula:
C23H25D4F3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluprostenol-d4 contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. It is intended for use as an internal standard for the quantification of fluprostenol by GC- or LC-mass spectrometry. Fluprostenol is a metabolically stable analog of prostaglandin F2α (PGF2α) with potent FP receptor agonist activity.11,2 It inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.1,2 Fluprostenol is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 · g/kg to terminate pregnancy.3 It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3-10 x 10-11 M.4
Fluprostenol-d4 References
1 Dukes, M., Russell, W., Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α Nature 250, 330-331 (1974). 2 Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Lett 355 317-325 (1994). 3 Abramovitz, M., Boie, Y., Nguyen, T., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem 269 2632-2636 (1994). 4 Serrero, G., Lepak, N.M. Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem Biophys Res Commun 233 200-202 (1997).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluprostenol-d4, 50 µg | sc-221621 | 50 µg | $42.00 | |||
Fluprostenol-d4, 100 µg | sc-221621A | 100 µg | $81.00 |