Molecular structure of Fluprostenol, CAS Number: 40666-16-8
Fluprostenol (CAS 40666-16-8)
Alternate Names:
(±)16-(m-Trifluoromethylphenoxy)-tetranor-prostaglandin F2α
Application:
Fluprostenol is a prostaglandin F (FP) receptor agonist
CAS Number:
40666-16-8
Purity:
98%
Molecular Weight:
458.47
Molecular Formula:
C23H29F3O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluprostenol is a PGF2αR (prostaglandin F (FP) receptor) agonist that is more selective than PGF2α (sc-201227). The compound can activate phosphorylation of ERK 2 (extracellular signal-regulated kinase (ERK)), p38-Mitogen-activated protein kinase (MAPK) and JNK3 (c-Jun N-terminal kinase (JNK)) in rat aortas. Studies have shown that it can induce phospholipase C and Ca+ mobilization in human myometrial cells and can decrease intraocular pressure (IOP) by improving aqueous humor outflow through the trabecular meshwork (TM) via inhibition of endothelin (ET)-1-dependent mechanisms. Fluprostenol also suppresses the expression of adipogenic genes in 3T3-L1 cells.
Fluprostenol (CAS 40666-16-8) References
- Use of short high-performance liquid chromatography columns and tandem-mass spectrometry for the rapid analysis of a prostaglandin analog, fluprostenol, in rat plasma. | Eichhold, TH., et al. 2000. J Chromatogr B Biomed Sci Appl. 741: 213-20. PMID: 10872591
- Semi-automated 96-well solid-phase extraction and gas chromatography-negative chemical ionization tandem mass spectrometry for the trace analysis of fluprostenol in rat plasma. | Gauw, RD., et al. 2000. J Chromatogr B Biomed Sci Appl. 744: 283-91. PMID: 10993516
- Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. | Thieme, H., et al. 2006. Invest Ophthalmol Vis Sci. 47: 938-45. PMID: 16505027
- Fluprostenol-induced MAPK signaling is independent of aging in Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta. | Rice, KM., et al. 2010. Ann Clin Lab Sci. 40: 26-31. PMID: 20124327
- Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes. | Mechiche, H., et al. 2012. PLoS One. 7: e45273. PMID: 22984630
- The prostaglandin f2α analog fluprostenol attenuates the fibrotic effects of connective tissue growth factor on human trabecular meshwork cells. | Fuchshofer, R., et al. 2014. J Ocul Pharmacol Ther. 30: 237-45. PMID: 24576038
- PTGFR activation promotes the expression of PTGS-2 and growth factors via activation of the PKC signaling pathway in bovine endometrial epithelial cells. | Gao, L., et al. 2018. Anim Reprod Sci. 199: 30-39. PMID: 30340853
- Prostaglandin F2α stimulates adhesion, migration, invasion and proliferation of the human trophoblast cell line HTR-8/SVneo. | Baryla, M., et al. 2019. Placenta. 77: 19-29. PMID: 30827352
- Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-κB p65. | Maehara, T. and Fujimori, K. 2020. Biochim Biophys Acta Mol Cell Biol Lipids. 1865: 158654. PMID: 32036038
- Protection of 6-OHDA neurotoxicity by PGF2α through FP-ERK-Nrf2 signaling in SH-SY5Y cells. | Sano, A., et al. 2021. Toxicology. 450: 152686. PMID: 33486071
- A General Catalyst Controlled Route to Prostaglandin F2α. | Cunningham, L., et al. 2022. Org Lett. 24: 8886-8889. PMID: 36446080
- Potent luteolytic agents related to prostaglandin F2alpha. | Dukes, M., et al. 1974. Nature. 250: 330-1. PMID: 4853720
- Fluprostenol-induced softening of the cervix of the pregnant rat. | Williams, LM., et al. 1983. J Endocrinol. 97: 283-90. PMID: 6304223
- Fluprostenol activates phospholipase C and Ca2+ mobilization in human myometrial cells. | Carrasco, MP., et al. 1996. J Clin Endocrinol Metab. 81: 2104-10. PMID: 8964835
- Actions of prostaglandin E2 on rat supraoptic neurones. | Sutarmo Setiadji, V., et al. 1998. J Neuroendocrinol. 10: 927-36. PMID: 9870750
Activator of:
PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluprostenol, 1 mg | sc-201336 | 1 mg | $62.00 | |||
Fluprostenol, 10 mg | sc-201336A | 10 mg | $510.00 |