Flupirtine-d4 Hydrochloride Salt
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Flupirtine-d4 Hydrochloride Salt is a labeled form of Flupirtine which acts as a selective neuronal potassium channel opener. Studies indicate that Flupirtine-d4 Hydrochloride Salt functions as a NMDA receptor antagonist. NMDA receptors are ionotropic receptors which send electrical signals between neurons of the brain and periphery. Studies show that Flupirtine-d4 Hydrochloride Salt specifically activates Kv7.4–Kv7.5 channels which relaxes smooth muscle. Researchers believe that the pyridine triamino structure of Flupirtine-d4 Hydrochloride Salt might be important in redox reactions. Alternate studies indicate that Flupirtine-d4 Hydrochloride Salt is used to prevent the neurodegeneration of brain tissue induced by tumor necrosis factor.
Flupirtine-d4 Hydrochloride Salt References
- Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. | Sättler, MB., et al. 2008. Am J Pathol. 173: 1496-507. PMID: 18832577
- Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. | Morecroft, I., et al. 2009. Br J Pharmacol. 157: 1241-9. PMID: 19508393
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flupirtine-d4 Hydrochloride Salt, 1 mg | sc-218513 | 1 mg | $360.00 |