Molecular structure of Fluoxetine hydrochloride, CAS Number: 56296-78-7
Fluoxetine hydrochloride (CAS 56296-78-7)
See product citations (14)
Alternate Names:
Fluoxetine hydrochloride is also known as LY110140.
Application:
Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor that reverses depressive-like behavior induced by unpredictable chronic mild stress.
CAS Number:
56296-78-7
Purity:
≥98%
Molecular Weight:
345.79
Molecular Formula:
C17H18F3NO•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluoxetine is an ST (5-hydroxytryptamine/serotonin/5-HT) reuptake inhibitor. This is a racemic mixture and both R and S enantiomers which are reported to inhibit 5-HT uptake in synaptosomal preparations of rat cerebral cortex. Additionally, Fluoxetine is also noted to increase extracellular levels of 5-HT in several areas of the rat brain as a result of reuptake inhibition. This increase in availability of 5-HT is reported to lead to a decrease in synthesis and turnover of 5-HT.
Fluoxetine hydrochloride (CAS 56296-78-7) References
- Carcinogenicity studies of fluoxetine hydrochloride in rats and mice. | Bendele, RA., et al. 1992. Cancer Res. 52: 6931-5. PMID: 1458482
- Gender based response to fluoxetine hydrochloride medication in endogenous depression. | Bano, S., et al. 2004. J Coll Physicians Surg Pak. 14: 161-5. PMID: 15228850
- Crystal engineering approach to forming cocrystals of amine hydrochlorides with organic acids. Molecular complexes of fluoxetine hydrochloride with benzoic, succinic, and fumaric acids. | Childs, SL., et al. 2004. J Am Chem Soc. 126: 13335-42. PMID: 15479089
- Uptake of the pharmaceutical Fluoxetine Hydrochloride from growth medium by Brassicaceae. | Redshaw, CH., et al. 2008. Phytochemistry. 69: 2510-6. PMID: 18723196
- Evaluation of in vitro percutaneous absorption of olanzapine and fluoxetine HCl: enhancement properties of olanzapine. | Borovinskaya, M., et al. 2012. Drug Dev Ind Pharm. 38: 227-34. PMID: 21864096
- Mice with ablated adult brain neurogenesis are not impaired in antidepressant response to chronic fluoxetine. | Jedynak, P., et al. 2014. J Psychiatr Res. 56: 106-11. PMID: 24931850
- Simultaneous determination of olanzapine and fluoxetine hydrochloride in capsules by spectrophotometry, TLC-spectrodensitometry and HPLC. | Tantawy, MA., et al. 2013. J Adv Res. 4: 173-80. PMID: 25685415
- Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. | Wong, DT., et al. 1995. Life Sci. 57: 411-41. PMID: 7623609
- Developmental toxicology studies of fluoxetine hydrochloride administered orally to rats and rabbits. | Byrd, RA. and Markham, JK. 1994. Fundam Appl Toxicol. 22: 511-8. PMID: 8056199
- Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac). | Ni, YG. and Miledi, R. 1997. Proc Natl Acad Sci U S A. 94: 2036-40. PMID: 9050900
- Fluoxetine selectively alters 5-hydroxytryptamine1A and gamma-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. | Beck, SG., et al. 1997. J Pharmacol Exp Ther. 281: 115-22. PMID: 9103487
- Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | Owens, MJ., et al. 1997. J Pharmacol Exp Ther. 283: 1305-22. PMID: 9400006
- Maillard reaction of lactose and fluoxetine hydrochloride, a secondary amine. | Wirth, DD., et al. 1998. J Pharm Sci. 87: 31-9. PMID: 9452965
- Pharmacological profile of antidepressants and related compounds at human monoamine transporters. | Tatsumi, M., et al. 1997. Eur J Pharmacol. 340: 249-58. PMID: 9537821
Inhibitor of:
C20orf95, C6orf100, CYP2C19, CYP2F1, CYP4X1, Neu, SLC6A (solute carrier family 6), ST, and TREK-2.Activator of:
GAD-67, IMPA3, Neuropeptide S, Paralemmin, PLP-J, and PSD-95.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluoxetine hydrochloride, 50 mg | sc-201125 | 50 mg | $75.00 | |||
Fluoxetine hydrochloride, 250 mg | sc-201125A | 250 mg | $209.00 | |||
Fluoxetine hydrochloride, 1 g | sc-201125B | 1 g | $399.00 | |||
Fluoxetine hydrochloride, 5 g | sc-201125C | 5 g | $849.00 |