Molecular structure of Fluorometholone, CAS Number: 426-13-1
Fluorometholone (CAS 426-13-1)
Alternate Names:
11β,17α-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
CAS Number:
426-13-1
Purity:
≥97%
Molecular Weight:
376.46
Molecular Formula:
C22H29FO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluorometholone is a potent anti-inflammatory agent. It acts by binding to the glucocorticoid receptor and subsequently modulating the transcription of various genes involved in the inflammatory response. This modulation leads to the suppression of the production of pro-inflammatory cytokines and other mediators of inflammation. Fluorometholone is known to inhibit the migration of leukocytes to sites of inflammation, thereby reducing the infiltration of inflammatory cells. At the cellular level, fluorometholone also exerts its effects by inhibiting the expression of adhesion molecules on endothelial cells. Fluorometholone′s mechanism of action involves the regulation of gene expression and the modulation of cellular processes that contribute to the inflammatory response.
Fluorometholone (CAS 426-13-1) References
- Do reducing regimens of fluorometholone for paediatric ocular surface disease cause glaucoma? | Mataftsi, A., et al. 2011. Br J Ophthalmol. 95: 1531-3. PMID: 21296793
- Effect of fluorometholone/tetrahydrozoline fixed combination on conjunctival autograft morphology after primary pterygium excision. | Ozgurhan, EB., et al. 2013. Biomed Res Int. 2013: 481843. PMID: 23865053
- Topical Fluorometholone Protects the Ocular Surface of Dry Eye Patients from Desiccating Stress: A Randomized Controlled Clinical Trial. | Pinto-Fraga, J., et al. 2016. Ophthalmology. 123: 141-53. PMID: 26520171
- Comparison of Loteprednol with Fluorometholone after Myopic Photorefractive Keratectomy. | Karimian, F., et al. 2017. J Ophthalmic Vis Res. 12: 11-16. PMID: 28299001
- Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. | Nättinen, J., et al. 2018. Ocul Surf. 16: 84-92. PMID: 28918083
- Comparison between Betamethasone, Fluorometholone and Loteprednol Etabonate on intraocular pressure in patients after keratorefractive surgery. | Shokoohi-Rad, S., et al. 2018. J Curr Ophthalmol. 30: 130-135. PMID: 29988925
- Fluorometholone 0.1% as Ancillary Therapy for Trachomatous Trichiasis Surgery: Randomized Clinical Trial. | Kempen, JH., et al. 2019. Am J Ophthalmol. 197: 145-155. PMID: 30267699
- Fluorometholone modulates gene expression of ocular surface mucins. | Taniguchi, J. and Sharma, A. 2019. Acta Ophthalmol. 97: e1082-e1088. PMID: 30963711
- The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes. | Baba, K., et al. 2021. Int J Pharm. 592: 120067. PMID: 33189813
- A topical fluorometholone nanoformulation fabricated under aqueous condition for the treatment of dry eye. | Wang, TZ., et al. 2022. Colloids Surf B Biointerfaces. 212: 112351. PMID: 35091382
- Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis. | Liu, SH., et al. 2022. Cochrane Database Syst Rev. 3: CD013520. PMID: 35238405
- Fluorometholone inhibits high glucose-induced cellular senescence in human retinal endothelial cells. | Zhou, X., et al. 2022. Hum Exp Toxicol. 41: 9603271221076107. PMID: 35264022
- Combination Therapy of 0.1% Fluorometholone and 0.05% Azelastine in Eyes with Severe Allergic Conjunctival Diseases: A Randomized Controlled Trial. | Chen, M., et al. 2022. J Clin Med. 11: PMID: 35807160
- Safety and efficacy of sodium cromoglycate-fluorometholone fixed combination eye drops in allergic conjunctivitis. | Alwadani, S. 2022. Saudi J Ophthalmol. 36: 107-112. PMID: 35971498
- Fluorometholone-induced cataract after photorefractive keratectomy. | Bilgihan, K., et al. 1997. Ophthalmologica. 211: 394-6. PMID: 9380362
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluorometholone, 100 mg | sc-235155 | 100 mg | $94.00 |