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FluoroGold™ (CAS 223769-64-0)

Name: FluoroGold&trade; | CAS 223769-64-0
Brand: SCBT
SKU: sc-358883
Price: 458.0 USD
Availability: InStock

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Alternate Names:

FluoroGold^™also known as Hydroxystilbamidine; Fluoro-Gold; Fluorgold

Application:

FluoroGold^™ is a highly effective neuronal retrograde tracer that is used similarly to other fluorescent tracers

CAS Number:

223769-64-0

Purity:

≥99%

Molecular Weight:

472.54

Molecular Formula:

C₁₆H₁₆N₄O•₂CH₄O₃S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data.

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Description

Technical Information

Safety Information

SDS & Certificate of Analysis

FluoroGold™ is a highly effective neuronal retrograde tracer compatible with any histological processing technique and can be further combined with a second marker such as autoradiography, HRP histochemistry, immunocytochemistry, a second fluorescent tracer, fluorescent counterstain, etc. FluoroGold™ can be used on virtually any central or peripheral nervous system structure for analysis of retrograde transport. In the peripheral nervous system, ganglia and peripheral targets can be studied. For studies of peripheral nerve, the nerve should be cut or damaged and either dipped in, or injected with a 5% solution of FluoroGold™. The survival time for FluoroGold™ should be varied and is dependent on the specific neuronal system under study. For retrograde transport, the survival times should be varied from 4 days to 14 days. In addition, since FluoroGold™ remains fast within retrogradely labeled neurons, survival times of several months will also produce excellent results. For iontophoresis, a 2-5 day survival time is recommended. It is estimated that transport occurs at about 2 cm per day for mammals, and is slower for cold-blooded animals.

FluoroGold™ (CAS 223769-64-0) References

Anatomy of olivocochlear neurons in the hamster studied with FluoroGold. | Sánchez-González, MA., et al. 2003. Hear Res. 185: 65-76. PMID: 14599694
Zincergic innervation of medial prefrontal cortex by basolateral projection neurons. | Cunningham, MG., et al. 2007. Neuroreport. 18: 531-5. PMID: 17413652
Dendrites of medial olivocochlear neurons in mouse. | Brown, MC. and Levine, JL. 2008. Neuroscience. 154: 147-59. PMID: 18313859
Projections of olfactory bulbs to the olfactory and vomeronasal cortices. | Pro-Sistiaga, P., et al. 2008. Neuroreport. 19: 1541-4. PMID: 18797313
Activation of serotonergic neurons during salicylate-induced tinnitus. | Caperton, KK. and Thompson, AM. 2011. Otol Neurotol. 32: 301-7. PMID: 21192277
Fluoro-Gold: a new fluorescent retrograde axonal tracer with numerous unique properties. | Schmued, LC. and Fallon, JH. 1986. Brain Res. 377: 147-54. PMID: 2425899
Calibration and standardisation of graded optic nerve injuries in rats. | Huang, HB., et al. 2015. Neurol Res. 37: 638-49. PMID: 25816832
The brainstem efferent acoustic chiasm in pigmented and albino rats. | Reuss, S., et al. 2016. Hear Res. 332: 1-6. PMID: 26657095
Enhancing Fluorogold-based neural tract tracing. | Mondello, SE., et al. 2016. J Neurosci Methods. 270: 85-91. PMID: 27288218
Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse. | Cádiz-Moretti, B., et al. 2017. J Comp Neurol. 525: 2929-2954. PMID: 28543083
The iontophoretic application of Fluoro-Gold for the study of afferents to deep brain nuclei. | Pieribone, VA. and Aston-Jones, G. 1988. Brain Res. 475: 259-71. PMID: 3214735
Phototoxicities Caused by Continuous Light Exposure Were Not Induced in Retinal Ganglion Cells Transduced by an Optogenetic Gene. | Tabata, K., et al. 2021. Int J Mol Sci. 22: PMID: 34201658
The parabrachio-subfornical organ projection in the rat. | Gu, GB. and Ju, G. 1995. Brain Res Bull. 38: 41-7. PMID: 7552374
Fluoro-gold and pentamidine inhibit the in vitro and in vivo release of dopamine in the striatum of rat. | Bowyer, JF., et al. 1993. J Pharmacol Exp Ther. 266: 1066-74. PMID: 8355181
Organization of inputs to the dorsomedial nucleus of the hypothalamus: a reexamination with Fluorogold and PHAL in the rat. | Thompson, RH. and Swanson, LW. 1998. Brain Res Brain Res Rev. 27: 89-118. PMID: 9622601

Ordering Information

Product Name	Catalog #	UNIT	Price	Qty	FAVORITES
FluoroGold™, 20 mg	sc-358883	20 mg	$458.00
FluoroGold™, 50 mg	sc-358883A	50 mg	$819.00

Can it be excited with a 405nm lazer?

Asked by: zmara

Thank you for your question. You will find this information in the Technical Information part on the webpage : λex 414 nm, λem 541 nm in 0.1% solution in distilled water (ph 4.5); λex 350-395 nm, λem 530-600 nm when bound to membranes at a physiological pH of 7.4 If you need additional information, please contact our Technical Service.

Answered by: Technical Support Europe

Date published: 2018-12-21

if i am planning to use fluorogold at 2% how much dH2O I need to dilute a bottle of 20 mg?

Asked by: luzum

Thank you for your question. We would recommend using 40 ml of water.

Answered by: Technical Support

Date published: 2024-03-28

What are the storage conditions once the material is in solution? How long can it be stored in solution?

Asked by: Jz28sail

Thank you for your question. The sc-358883, FluoroGold™ dye in solution is light sensitive and should be stored in a light-tight container, tightly sealed at 4°C. If stored properly, the dye in solution should remain stable for 6 months.

Answered by: Chemical Support 5

Date published: 2023-02-10

Rated 2 out of 5 by Majsan from The delivery was quick and without problems.We received FluoroGold two weeks ago and we have still not seen anything but negative results. The answer from technical support of the dilution of 20 mg of FG is completely wrong. You will get a concentration of 0,05% if you dilute 20 mg FG in 40 ml of water.

Date published: 2018-09-26

Rated 5 out of 5 by ET from Various publications cite FluoroGold asVarious publications cite FluoroGold as a highly effective neuronal retrograde tracer, compatible with any histological processing technique and can be further combined with a second marker. -SCBT Publication Review

Date published: 2015-03-04

FluoroGold™ is rated 3.5 out of 5 by 2.

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Test	Specification	Results
Appearance	golden-yellow, hygroscopic, crystalline powder	Bright-yellow powder
Assay	95.0 - 105.0%	99.2%
pH	4.0-5.5 (1% solution at 25°C)	4.6
Solution	20 ml of a 5% w/v aqueous solution should be clean, clear and almost free from suspended matter, and should have not more than a very slight odor	Complies
Heavy Metals	≤ 10 ppm	< 10 ppm
Loss on Drying	≤ 1.0% (3 hours in vacuo at 60°C)	0.1%
Chloride	≤ 0.035%	0.017%
Selenium	≤ 30 ppm	< 10 ppm
Sulfate	≤ 0.1%	< 0.05%
Sulfated Ash	≤ 0.1%	Negligible

FluoroGold™ (CAS 223769-64-0)

FluoroGold™ (CAS 223769-64-0) References

SAMPLE Certificate of Analysis (COA)

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FluoroGold™, 20 mg

FluoroGold™, 50 mg

Can it be excited with a 405nm lazer?

if i am planning to use fluorogold at 2% how much dH2O I need to dilute a bottle of 20 mg?

What are the storage conditions once the material is in solution? How long can it be stored in solution?