Molecular structure of Fluoroacetamide, CAS Number: 640-19-7
Fluoroacetamide (CAS 640-19-7)
Application:
Fluoroacetamide is A rodenticide.
CAS Number:
640-19-7
Molecular Weight:
77.06
Molecular Formula:
FCH2CONH2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluoroacetamide presents itself as a colorless crystalline powder and serves as a rodenticide. This compound exhibits high toxicity. Specifically, Fluoroacetamide refers to acetamide with a fluorine atom substitution at position C-2. The toxic mechanism of fluoroacetate involves the inhibition of the citric acid cycle. The fluorine-substituted acetate is incorporated, behaving like a regular acetate, into fluorocitrate coenzyme A. This coenzyme then combines with oxaloacetate, forming fluorocitrate. Fluorocitrate hinders the enzyme aconitase, thereby impeding the conversion of citrate to isocitrate. Consequently, there is an accumulation of substantial amounts of citrate in the tissues, leading to cycle blockage. Notably, poisoning resulting from general oxidative energy metabolism inhibition critically affects the heart and central nervous system (CNS).
Fluoroacetamide (CAS 640-19-7) References
- Isolation and phenotypic characterization of Pseudomonas aeruginosa pseudorevertants containing suppressors of the catabolite repression control-defective crc-10 allele. | Collier, DN., et al. 2001. FEMS Microbiol Lett. 196: 87-92. PMID: 11267761
- [Analysis of fluoroacetamide in biological samples with GC/NPD, GC/FID]. | Feng, SZ. and Yu, ZS. 1999. Fa Yi Xue Za Zhi. 15: 91-2, 125. PMID: 12536408
- [Simultaneous determination of fluoroacetamide and tetramine by gas chromatography]. | Wu, Q., et al. 2002. Se Pu. 20: 381-2. PMID: 12541932
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- Fast detection of fluoroacetamide in body fluid using gas chromatography-mass spectrometry after solid-phase microextraction. | Cai, X., et al. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 802: 239-45. PMID: 15018783
- Electrophysiological study of infant and adult rats under acute intoxication with fluoroacetamide. | Kuznetsov, SV., et al. 2007. J Appl Toxicol. 27: 538-50. PMID: 17351914
- Simultaneous determination of two acute poisoning rodenticides tetramine and fluoroacetamide with a coupled column in poisoning cases. | Xu, X., et al. 2008. J Chromatogr B Analyt Technol Biomed Life Sci. 876: 103-8. PMID: 18993117
- Enzymatic defluorination and metabolism of fluoroacetate, fluoroacetamide, fluoroethanol, and (-)-erythro-fluorocitrate in rats and mice examined by 19F and 13C NMR. | Tecle, B. and Casida, JE. 1989. Chem Res Toxicol. 2: 429-35. PMID: 2519733
- In vitro selection of DNA aptamers binding pesticide fluoroacetamide. | Cao, F., et al. 2016. Biosci Biotechnol Biochem. 80: 823-32. PMID: 26873572
- Lessons learned from poisoning cases caused by 2 illegal rodenticides: Tetramine and fluoroacetamide. | Wang, R., et al. 2016. Medicine (Baltimore). 95: e5103. PMID: 27741126
- Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc-Containing Sugars: Modulation of the CH-π Stacking Interactions by Different Fluorination Patterns. | Unione, L., et al. 2017. Chemistry. 23: 3957-3965. PMID: 28124793
- Hapten Design and Monoclonal Antibody to Fluoroacetamide, a Small and Highly Toxic Chemical. | Yang, L., et al. 2020. Biomolecules. 10: PMID: 32630260
- Reversible leukoencephalopathy caused by 2 rodenticides bromadiolone and fluoroacetamide: A case report and literature review. | Lu, A., et al. 2021. Medicine (Baltimore). 100: e25053. PMID: 33655984
- Fluoroacetamide resistance mutations in Chlamydomonas reinhardtii. | Hodson, RC. and Gresshoff, PM. 1987. Arch Microbiol. 148: 8-13. PMID: 3632232
- The role of fluoroacetate-specific dehalogenase and glutathione transferase in the metabolism of fluoroacetamide and 2,4-dinitrofluorobenzene. | Kostyniak, PJ. and Soiefer, AI. 1984. Toxicol Lett. 22: 217-22. PMID: 6147909
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Urease beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluoroacetamide, 5 g | sc-250002 | 5 g | $162.00 |