Fluorescein-O′-acetic acid (CAS 233759-98-3)
QUICK LINKS
Fluorescein-O′-acetic acid (FOA) is a fluorescent label which reacts with amines after activation to give isomerically homogeneous derivatives. It is used to study the metabolism of cells, to identify and quantify cellular components, and to measure enzyme activities. FOA is taken up by cells and converted to fluorescein-O-acetyl-ester. This is then hydrolyzed by intracellular esterases to form fluorescein, which is excreted from the cell. This process results in the cell accumulating a fluorescent signal that can be used to study cellular processes. Fluorescein-O-acetyl-ester may act to inhibit the activity of some enzymes, increase the permeability of cell membranes, induce apoptosis in some cell types, and induce the production of reactive oxygen species in cells.
Fluorescein-O′-acetic acid (CAS 233759-98-3) References
- Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5. | Arsova, A., et al. 2020. Mol Pharmacol. 98: 49-60. PMID: 32358164
- Quantification of Molecular Interactions in Living Cells in Real Time using a Membrane Protein Nanopattern. | Reichmuth, AM., et al. 2020. Anal Chem. 92: 8983-8991. PMID: 32524822
- Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. | Willard, FS., et al. 2020. JCI Insight. 5: PMID: 32730231
- Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis. | Sundqvist, M., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118849. PMID: 32916203
- Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells. | Møller, TC., et al. 2020. Sci Rep. 10: 17395. PMID: 33060647
- Arrestin-Dependent and -Independent Internalization of G Protein-Coupled Receptors: Methods, Mechanisms, and Implications on Cell Signaling. | Moo, EV., et al. 2021. Mol Pharmacol. 99: 242-255. PMID: 33472843
- GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats. | van der Velden, WJC., et al. 2021. ACS Pharmacol Transl Sci. 4: 296-313. PMID: 33615180
- Loss of Function Glucose-Dependent Insulinotropic Polypeptide Receptor Variants Are Associated With Alterations in BMI, Bone Strength and Cardiovascular Outcomes. | Kizilkaya, HS., et al. 2021. Front Cell Dev Biol. 9: 749607. PMID: 34760890
- Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139. | Pallareti, L., et al. 2023. Eur J Pharmacol. 943: 175553. PMID: 36736525
- Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis. | Mavri, M., et al. 2023. Cell Mol Biol Lett. 28: 14. PMID: 36810008
- Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization. | Kjær, VMS., et al. 2023. Sci Signal. 16: eabl4283. PMID: 37014928
- Endocytic proteins mediating GPR15 receptor internalization provide insight into the underlying mechanisms. | Deng, Y., et al. 2023. FEBS Lett.. PMID: 37051832
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluorescein-O′-acetic acid, 5 mg | sc-215045 | 5 mg | $107.00 | |||
Fluorescein-O′-acetic acid, 25 mg | sc-215045A | 25 mg | $398.00 |