Molecular structure of Fluocinolone Acetonide, CAS Number: 67-73-2
Fluocinolone Acetonide (CAS 67-73-2)
Application:
Fluocinolone Acetonide is a synthetic glucocorticoid VEGF inhibitor
CAS Number:
67-73-2
Purity:
≥98%
Molecular Weight:
452.49
Molecular Formula:
C24H30F2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluocinolone Acetonide is a synthetic glucocorticoid which acts as an inhibitor of tumor cells. Studies indicate that Fluocinolone Acetonide can inhibit promotion of tumor cells at an early stage of promotion if combined with a promoting agent. In addition, studies suggest that Fluocinolone Acetonide can regulate lipid metabolism by modulating gene expression. Alternate studies show that Fluocinolone Acetonide can inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, Fluocinolone Acetonide can inhibit TNF-alpha angiogenesis.
Fluocinolone Acetonide (CAS 67-73-2) References
- Fluocinolone acetonide ophthalmic--Bausch & Lomb: fluocinolone acetonide Envision TD implant. | . 2005. Drugs R D. 6: 116-9. PMID: 15777105
- Expression of TNF-alpha in oral lichen planus treated with fluocinolone acetonide 0.1%. | Thongprasom, K., et al. 2006. J Oral Pathol Med. 35: 161-6. PMID: 16454812
- Fluocinolone inhibits VEGF expression via glucocorticoid receptor in human retinal pigment epithelial (ARPE-19) cells and TNF-alpha-induced angiogenesis in chick chorioallantoic membrane (CAM). | Ayalasomayajula, SP., et al. 2009. J Ocul Pharmacol Ther. 25: 97-103. PMID: 19284324
- Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. | Nehmé, A., et al. 2009. BMC Med Genomics. 2: 58. PMID: 19744340
- Fluocinolone acetonide promotes the proliferation and mineralization of dental pulp cells. | Liu, Z., et al. 2013. J Endod. 39: 217-22. PMID: 23321234
- Fluocinolone acetonide intravitreal implant (Iluvien®): in diabetic macular oedema. | Sanford, M. 2013. Drugs. 73: 187-93. PMID: 23335133
- Fluocinolone acetonide intravitreal implant for the treatment of diabetic macular edema. | Messenger, WB., et al. 2013. Drug Des Devel Ther. 7: 425-34. PMID: 23737661
- Sustained-release fluocinolone acetonide intravitreal insert for macular edema: clinical pharmacology and safety evaluation. | Sadiq, MA., et al. 2015. Expert Opin Drug Saf. 14: 1147-56. PMID: 25994877
- Fluocinolone Acetonide Intravitreal Implant 0.19 mg (ILUVIEN®): A Review in Diabetic Macular Edema. | Syed, YY. 2017. Drugs. 77: 575-583. PMID: 28283896
- Fluocinolone acetonide for the treatment of diabetic macular edema. | Veritti, D., et al. 2017. Expert Opin Pharmacother. 18: 1507-1516. PMID: 28764565
- Preliminary evaluation of YUTIQ™ (fluocinolone acetonide intravitreal implant 0.18 mg) in posterior uveitis. | Testi, I. and Pavesio, C. 2019. Ther Deliv. 10: 621-625. PMID: 31663454
- Intravitreal methotrexate and fluocinolone acetonide implantation for Vogt-Koyanagi-Harada uveitis. | Park, JG., et al. 2020. Am J Ophthalmol Case Rep. 19: 100859. PMID: 32793845
- Switching to intravitreal fluocinolone acetonide implant for refractory diabetic macular edema: 12- and 24-month results. | Chronopoulos, A., et al. 2022. Eur J Ophthalmol. 32: 443-449. PMID: 33601897
- Fluocinolone acetonide implant (Iluvien®) for macular edema associated with retinitis pigmentosa: A case report. | Jomaa, E., et al. 2022. Eur J Ophthalmol. 11206721221144141. PMID: 36474351
Inhibitor of:
Angiogenesis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluocinolone Acetonide, 25 mg | sc-204756 | 25 mg | $32.00 | |||
Fluocinolone Acetonide, 100 mg | sc-204756A | 100 mg | $48.00 | |||
Fluocinolone Acetonide, 1 g | sc-204756B | 1 g | $257.00 | |||
Fluocinolone Acetonide, 5 g | sc-204756C | 5 g | $867.00 |