Molecular structure of FLUO 3/AM, CAS Number: 121714-22-5
FLUO 3/AM (CAS 121714-22-5)
See product citations (11)
Alternate Names:
Fluo-3, AM
Application:
FLUO 3/AM is a visible wavelength calcium probe capable of indicating changes in Ca2+ levels
CAS Number:
121714-22-5
Purity:
≥88%
Molecular Weight:
1129.85
Molecular Formula:
C51H50Cl2N2O23
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FLUO 3/AM, a visible wavelength calcium probe, can be detected through fluorescent cytometry. Experiments show that this compound can be loaded into lymphocytes and fibroblasts by incubation with the pentaacetoxymethyl ester of the dye. Once inside the cell, the ester is hydrolyzed to yield genuine FLUO-3/AM capable of indicating changes in Ca2+. Other studies have reported that this FLUO 3/AM monitors Ca2+ levels without interfering with intracellular conditions. Additionally, this agent has been noted to be an effective probe for assessing the concentration and kinetics of change in mitochondrial Ca2+ under variety of conditions.
FLUO 3/AM (CAS 121714-22-5) References
- Flow cytometric kinetic assay of calcium mobilization in whole blood platelets using Fluo-3 and CD41. | do Céu Monteiro, M., et al. 1999. Cytometry. 35: 302-10. PMID: 10213195
- Role of calcium in acute hyperthermic myocardial injury. | Everett, TH., et al. 2001. J Cardiovasc Electrophysiol. 12: 563-9. PMID: 11386518
- [Relationship between multidrug resistance in human colon carcinoma LoVo/Adr cell line and intracellular calcium ion concentration]. | Ma, Q., et al. 2002. Ai Zheng. 21: 846-9. PMID: 12478890
- Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. | Loughrey, CM., et al. 2003. Cell Calcium. 34: 1-9. PMID: 12767887
- Platelet-activating factor stimulates arachidonic acid release and enhances thromboxane B2 production in intact fetal rat brain ex vivo. | Kunievsky, B. and Yavin, E. 1992. J Pharmacol Exp Ther. 263: 562-8. PMID: 1432689
- Fast loading ester fluorescent Ca2+ and pH indicators into pollen of Pyrus pyrifolia. | Qu, H., et al. 2012. J Plant Res. 125: 185-95. PMID: 21789557
- Control of mitochondrial matrix calcium: studies using fluo-3 as a fluorescent calcium indicator. | Saavedra-Molina, A., et al. 1990. Biochem Biophys Res Commun. 167: 148-53. PMID: 2310386
- Photochemically generated cytosolic calcium pulses and their detection by fluo-3. | Kao, JP., et al. 1989. J Biol Chem. 264: 8179-84. PMID: 2498309
- Anti-Cancer Effects of 3, 3'-Diindolylmethane on Human Hepatocellular Carcinoma Cells Is Enhanced by Calcium Ionophore: The Role of Cytosolic Ca2+ and p38 MAPK. | Jiang, Y., et al. 2019. Front Pharmacol. 10: 1167. PMID: 31649538
- Fluo-3 signals associated with potassium contractures in single amphibian muscle fibres. | Caputo, C. and Bolaños, P. 1994. J Physiol. 481 (Pt 1): 119-28. PMID: 7853234
- Recombinant human tumor necrosis factor alpha induces calcium oscillation and calcium-activated chloride current in human neutrophils. The role of calcium/calmodulin-dependent protein kinase. | Schumann, MA., et al. 1993. J Biol Chem. 268: 2134-40. PMID: 8380590
- Loading and localization of Fluo-3 and Fluo-3/AM calcium indicators in sinapis alba root tissue. | Tretyn, A., et al. 1997. Folia Histochem Cytobiol. 35: 41-51. PMID: 9090510
- SUN-263 Fluo-3/AM labelling as a sensitive method in the diagnosis of calciphylaxis | X. Zhu, et al. March 2020. Kidney International Reports. Volume 5, ISSUE 3,: SUPPLEMENT, S309,.
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EYA1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FLUO 3/AM, 1 mg | sc-202612 | 1 mg | $265.00 |