Flunarizine • 2HCl (CAS 30484-77-6)
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Flunarizine • 2HCl, a calcium channel protein inhibitor and antagonist, may act to inhibit contraction of isolated murine caudal artery preparations. Mechanistic studies suggest that this compound inhibits prostaglandin-induced and Serotonin • HCl (sc-201146) induced components of the contraction via reduction in the amounts of TXB2 (Thromboxane B2) (sc-201452) and ALK-1, and an increase in production of HETE. Experiments on rabbit sino-atrial nodes and isolated guinea-pig papillary muscles have reported that Flunarizine • 2HCl depressed the slow action potentials of K+-depolarized papillary muscle. Additionally, studies indicate that Flunarizine • 2HCl selectively suppresses Ca2+ influx through the cell membrane of sino-atrial nodes.
Flunarizine • 2HCl (CAS 30484-77-6) References
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- INVESTIGATION AND OPTIMIZATION OF TITRIMETRIC AND SPECTROPHOTOMETRIC METHODS FOR THE ASSAY OF FLUNARIZINE DIHYDROCHLORIDE USING IN SITU BROMINE. | Prashanth, KN., et al. 2016. Acta Pol Pharm. 73: 35-45. PMID: 27008799
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- Actions of flunarizine dihydrochloride on the electrical activity of isolated guinea-pig papillary muscle and rabbit sino-atrial node. | Kotake, H., et al. 1988. Res Commun Chem Pathol Pharmacol. 62: 147-60. PMID: 3251331
- Platelet-mediated vascular contractions. Inhibition by flunarizine, a calcium-entry blocker. | De Clerck, F. and Van Nueten, JM. 1983. Biochem Pharmacol. 32: 765-71. PMID: 6404280
- Liquid chromatographic determination of flunarizine dihydrochloride in the presence of its degradation product. | Wahbi, AA., et al. 1995. J Pharm Biomed Anal. 13: 777-84. PMID: 7669832
- Spectrophotometric determination of flunarizine dihydrochloride through the formation of charge-transfer complex with iodine. | el Walily, AF., et al. 1995. J Pharm Biomed Anal. 13: 53-8. PMID: 7718634
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flunarizine • 2HCl, 1 g | sc-201473 | 1 g | $68.00 | |||
Flunarizine • 2HCl, 10 g | sc-201473A | 10 g | $400.00 | |||
Flunarizine • 2HCl, 50 g | sc-201473B | 50 g | $1683.00 |