Molecular structure of Fluindione, CAS Number: 957-56-2
Fluindione (CAS 957-56-2)
See product citations (2)
Alternate Names:
2-(4-Fluorophenyl)-1H-indene-1,3(2H)-dione; 2-(p-Fluorophenyl)-1,3-indandione; LM 123; Previscan
Application:
Fluindione is a vitamin K antagonist
CAS Number:
957-56-2
Molecular Weight:
240.23
Molecular Formula:
C15H9FO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Fluindione is a hematologic agent and a vitamin K antagonist. Additionally, Fluindione has been studied for its effectiveness in addressing Blood Coagulation Disorders. As a vitamin K antagonist, Fluindione inhibits vitamin K epoxide reductase (VKOR) with an IC50 of 6.6 nM, including VKOR with specific substitution mutations. It also hinders platelet and fibrin deposition, as well as prevents the release of β-thromboglobulin and the formation of thrombin-antithrombin complexes. These effects have been observed in an ex vivo model using isolated human whole blood and induced thrombus formation through tissue factor.
Fluindione (CAS 957-56-2) References
- [Hypersensitivity to fluindione (Previscan). Positive skin patch tests]. | Frouin, E., et al. 2005. Ann Dermatol Venereol. 132: 1000-2. PMID: 16446646
- Acute immuno-allergic interstitial nephritis caused by fluindione. | Belmouaz, S., et al. 2006. Clin Nephrol. 66: 455-8. PMID: 17176918
- Interactions between herbal medicines and prescribed drugs: an updated systematic review. | Izzo, AA. and Ernst, E. 2009. Drugs. 69: 1777-98. PMID: 19719333
- Immunoallergic adverse effects of fluindione. | . 2010. Prescrire Int. 19: 255-6. PMID: 21284358
- Fluindione and drug reaction with eosinophilia and systemic symptoms: an unrecognised adverse effect? | Daveluy, A., et al. 2012. Eur J Clin Pharmacol. 68: 101-5. PMID: 21792562
- Acute and chronic nephropathy induced by fluindione must be addressed. | Cam, G., et al. 2012. Nephrol Dial Transplant. 27: 1554-8. PMID: 21931126
- Pharmacokinetic and pharmacodynamic variability of fluindione in octogenarians. | Comets, E., et al. 2012. Clin Pharmacol Ther. 91: 777-86. PMID: 22472992
- A model predicting fluindione dose requirement in elderly inpatients including genotypes, body weight, and amiodarone. | Moreau, C., et al. 2014. Thromb Haemost. 111: 705-12. PMID: 24337438
- [Agranulocytosis related to fluindione: A case report]. | Ngo, S., et al. 2016. Rev Med Interne. 37: 58-61. PMID: 26096756
- Reversible Fluindione-Induced Chronic Interstitial Nephritis. | Crepin, T., et al. 2016. Case Rep Nephrol. 2016: 9818195. PMID: 27127666
- [Comparative study in primary care of the stability of INR in patients treated with warfarin or fluindione for atrial fibrillation. The FLOWER study (FLuindione Or WarfarinE - Result INR)]. | Giron, A., et al. 2022. Ann Cardiol Angeiol (Paris). 71: 123-129. PMID: 35039141
- Patch testing in drug reaction with eosinophilia and systemic symptoms (DRESS): A literature review. | de Groot, AC. 2022. Contact Dermatitis. 86: 443-479. PMID: 35233782
- [Not Available]. | Quach Hiep, TT., et al. 2022. Ann Biol Clin (Paris). 80: 133-140. PMID: 35766064
- Modeling INR data to predict maintenance fluindione dosage. | Comets, E., et al. 1998. Ther Drug Monit. 20: 631-9. PMID: 9853979
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluindione, 25 mg | sc-211518 | 25 mg | $320.00 |