Molecular structure of Fludrocortisone-d5, CAS Number: 127-31-1 (unlabeled)
Fludrocortisone-d5 (CAS 127-31-1 (unlabeled))
Application:
Fludrocortisone-d5 is a labeled synthetic corticosteroid
CAS Number:
127-31-1 (unlabeled)
Molecular Weight:
385.48
Molecular Formula:
C21H24D5FO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fludrocortisone-d5 is a labeled mineralcorticoid which can increase plasma fluid retention and volume. Structurally Fludrocortisone-d5 is identical to cortisol at every position except one hydrogen is replaced with a fluorine. Studies suggest that Fludrocortisone-d5 may sensitize vascular receptors to pressor amines. It has been observed that mineralcorticoids can increase the intracellular sodium concentration and decrease intracellular potassium. These studies suggest that Fludrocortisone-d5 alters the properties of adrenergic receptors as a result of a shift in intracellular cations.
Fludrocortisone-d5 (CAS 127-31-1 (unlabeled)) References
- A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra-high-performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application. | Banda, J., et al. 2015. Biomed Chromatogr. 29: 1213-9. PMID: 25611194
- Assessing treatment adherence is crucial to determine adequacy of mineralocorticoid therapy. | Pofi, R., et al. 2023. Endocr Connect. 12: PMID: 37410094
- Fludrocortisone in orthostatic hypotension. | Decaux, G. 1979. N Engl J Med. 301: 1121-2. PMID: 492260
- Flurbiprofen and fludrocortisone in severe autonomic neuropathy. | Perkins, CM. and Lee, MR. 1978. Lancet. 2: 1058. PMID: 82081
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fludrocortisone-d5, 1 mg | sc-218493 | 1 mg | $430.00 |