Flucloxacillin sodium (CAS 1847-24-1)

Flucloxacillin sodium, with the CAS number 1847-24-1, is a sodium salt form of flucloxacillin, a beta-lactam antibiotic that belongs to the penicillinase-resistant group of penicillins. This compound is known for its ability to resist degradation by staphylococcal penicillinase enzymes, which are commonly involved in antibiotic resistance. The principal mechanism of action of Flucloxacillin sodium involves the inhibition of bacterial cell wall synthesis. It achieves this by binding to penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. These PBPs are enzymes that play a critical role in the cross-linking process of the bacterial cell wall′s peptidoglycan layer, which is essential for maintaining cell wall integrity and shape. By inhibiting these proteins, Flucloxacillin sodium disrupts the final stages of the bacterial cell wall assembly, leading to weakened cell walls, ultimately causing bacterial lysis and cell death. In research, Flucloxacillin sodium has been extensively used to study the dynamics of bacterial cell wall synthesis, the mechanism of action of beta-lactam antibiotics, and the molecular basis of resistance to penicillinase-producing bacteria. These investigations are crucial for understanding bacterial cell physiology, the development of bacterial resistance, and exploring new strategies to counteract resistant bacterial strains.