FLJ23356 Antibody (S-23): sc-100433

FLJ23356 Antibody (S-23) is a mouse monoclonal IgG1 kappa light chain antibody that detects the FLJ23356 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FLJ23356 antibody (S-23) is available as the non-conjugated form. FLJ23356 protein, also known as Sugen kinase 196, SGK196, or protein kinase-like protein SgK196, is a 350 amino acid protein that belongs to the Serine/Threonine protein kinase family. Notably, FLJ23356 is characterized by its unique structure, which includes a kinase domain that is believed to be catalytically inactive. This structural feature suggests that FLJ23356 may play a regulatory role rather than a direct catalytic one in cellular signaling pathways. A glycine-to-serine substitution motif at subdomain VII of FLJ23356′s catalytic domain indicates potential functional implications, possibly affecting protein interactions or signaling cascade modulation. Serine/Threonine kinases are crucial for various cellular processes, including division, proliferation, differentiation, and apoptosis, making FLJ23356 particularly important for understanding these fundamental biological functions.

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FLJ23356 Antibody (S-23) References:

1. Evolution of protein kinase signaling from yeast to man.  |  Manning, G., et al. 2002. Trends Biochem Sci. 27: 514-20. PMID: 12368087
2. High-throughput structural biology in drug discovery: protein kinases.  |  Stout, TJ., et al. 2004. Curr Pharm Des. 10: 1069-82. PMID: 15078142
3. Creating chemical diversity to target protein kinases.  |  Li, B., et al. 2004. Comb Chem High Throughput Screen. 7: 453-72. PMID: 15320712
4. LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.  |  Jaleel, M., et al. 2007. Biochem J. 405: 307-17. PMID: 17447891
5. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members.  |  Hanks, SK. and Quinn, AM. 1991. Methods Enzymol. 200: 38-62. PMID: 1956325
6. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.  |  Hanks, SK., et al. 1988. Science. 241: 42-52. PMID: 3291115
7. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.  |  Hanks, SK. and Hunter, T. 1995. FASEB J. 9: 576-96. PMID: 7768349

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FLJ23356 Antibody (S-23) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-FLJ23356 Antibody (S-23) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FLJ23356 Antibody (S-23) Specifications

Alternate Product Name: FLJ23356

Product Clone Name: S-23

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 251-351

Epitope Target: FLJ23356

Epitope Species: human

Product Reactivity/Detection: FLJ23356

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for FLJ23356 Antibody (S-23): N/A