FlAsH-EDT2 CAS: 212118-77-9
MF: C24H18As2O5S4
MW: 664.50

FlAsH-EDT2 (CAS 212118-77-9)

FlAsH-EDT2 | CAS 212118-77-9 is rated 5.0 out of 5 by 1.
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Alternate Names: FlAsH-EDT2 also known as 4,5-Bis(1,3,2-dithiarsolan-2-yl)-3,6-dihydroxyspiro[isobenzofuran-1(3H),9-[9H]xanthen]-3-one; FlAsH; Fluorescein Arsenical Helix Binder; Lumio Green
Application: FlAsH-EDT2 is a membrane permeant fluorogenic biarsenical fluorescence probe for labeling proteins
CAS Number: 212118-77-9
Molecular Weight: 664.50
Molecular Formula: C24H18As2O5S4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

FlAsH-EDT2 is a fluorescence probe for labeling proteins. The Fluorescein Arsenical Hairpin Binder (FlAsH) method is presented for fluorescence labeling of proteins in living cells. Labeling proteins with the membrane-permeant fluorogenic biarsenical dye fluorescein arsenical hairpin binder-ethanedithiol (FlAsH-EDT2). The membrane-permeant fluorogenic biarsenicals FlAsH-EDT2 and ReAsH-EDT2 can be prepared in good yields by a straightforward two-step procedure from the inexpensive precursor dyes fluorescein and resorufin. FlAsH-EDT2 binds covalently to a tetracysteine sequence (CCPGCC).

Physical State :
Solid
Solubility :
Soluble in chloroform.
Storage :
Store at -20° C
Melting Point :
169-172° C (dec.)
Boiling Point :
849.8° C at 760 mmHg (Predicted)
Fluoresence :
λex 508 nm, λem 528 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9831137
MDL Number :
MFCD07437941
SMILES :
C1CS[As](S1)C2=C(C=CC3=C2OC4=C(C35C6=CC=CC=C6C(=O)O5)C=CC(=C4[As]7SCCS7)O)O

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FlAsH-EDT2 (CAS 212118-77-9) Product Citations

See how others have used FlAsH-EDT2 (CAS 212118-77-9). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 29275539  Fang, GM.|Seitz, O.| et al. 2017. Curr Protoc Nucleic Acid Chem. 71: 4.78.1-4.78.14.

PMID: # 31836717  Nat Commun. 10: 5708.

PMID: # 32284329  J. Biol. Chem.

Citations 1 to 3 of 3 total

Can FlAsH-EDT2 be stored in DMSO or DMF and if so for how long at which conditions?

Asked by: Jaro
Thank you for your question. FlAsH-EDT2 (CAS 212118-77-9) is slightly soluble in chloroform and methanol. We recommend storing it in its solid form at -20 °C and preparing working solutions fresh to prevent degradation or precipitation of the solute. For further questions please contact technical service directly.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

Is this soluble in DMF?

Asked by: vanesp
Thank you for your question. This is soluble in DMF at 15mg/ml respectively, and should be purged with an inert gas.
Answered by: Technical Service
Date published: 2018-03-06

Has it been tried to target FlAsH-EDT2 with antibodies against fluorescein ? Or more generally, are there antibodies against FlAsH-EDT2 ?

Asked by: TTTT
Thank you for your question. We do not currently offer any antibodies against FlAsH-EDT2. We also are not aware of any publications citing use of the use of this FlAsH-EDT2 (CAS 212118-77-9) flourescent probe with antibodies against flourescein.
Answered by: Technical Support
Date published: 2017-03-06

Is this soluble in DMSO?

Asked by: SCchem16
Thank you for your question. This chemical, FlAsH-EDT2 (CAS 212118-77-9), is only partially soluble in DMSO.
Answered by: Chemical Support 2
Date published: 2017-02-28

This structure differs from ones reported elsewhere (e.g. in the original publication or on: en.wikipedia.org/wiki/FlAsH-EDT2). These other sources report a free carboxylic group on the 3rd carbon whereas you report a lactone. Which is correct?

Asked by: AndrewH
Thank you for your question. Regarding compound FlAsH-EDT2 (CAS 212118-77-9), the structures are just tautomers of each other - they will interconvert, and both are correct.
Answered by: Technical Support
Date published: 2017-01-24
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Rated 5 out of 5 by from Various publications cite FlAsH Various publications cite FlAsH-EDT2 as a fluorescence probe for labeling proteins. The Fluorescein Arsenical Hairpin Binder (FlAsH) method is presented for fluorescence labeling of proteins in living cells. The membrane-permeant fluorogenic biarsenicals FlAsH-EDT2 and ReAsH-EDT2 can be prepared in good yields by a straightforward two-step procedure from the inexpensive precursor dyes fluorescein and resorufin. -SCBT Publication Review
Date published: 2015-06-01
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