Molecular structure of FKGK 11, CAS Number: 1071000-98-0
FKGK 11 (CAS 1071000-98-0)
Alternate Names:
1,1,1,2,2-pentafluoro-7-phenyl-3-heptanone
Application:
FKGK 11 is a selective inhibitor of iPLA2
CAS Number:
1071000-98-0
Purity:
≥98%
Molecular Weight:
280.24
Molecular Formula:
C13H13F5O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a lysophospholipid and a free fatty acid as products. There are three broad classes of PLA2, secretory (sPLA2), calcium-independent cytosolic (iPLA2), and calcium-dependent cytosolic (cPLA2), that have different functions. FKGK 11 is a selective inhibitor of iPLA2 that demonstrates an XI(50) value of 0.0073, where XI(50) equals the mole fraction of FKGK 11 in the total substrate interface required to inhibit iPLA2 by 50% (1). In comparison, mole fractions as high as 0.091 do not inhibit cPLA2 activity and cause only minute inhibition of sPLA2 (1).
FKGK 11 (CAS 1071000-98-0) References
- Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. | Baskakis, C., et al. 2008. J Med Chem. 51: 8027-37. PMID: 19053783
- Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb. | Paliege, A., et al. 2012. Am J Physiol Renal Physiol. 302: F865-74. PMID: 22218592
- Combined targeted Omic and Functional Assays Identify Phospholipases A₂ that Regulate Docking/Priming in Calcium-Triggered Exocytosis. | Dabral, D. and Coorssen, JR. 2019. Cells. 8: PMID: 30986994
- Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages. | Akhade, AS., et al. 2020. Proc Natl Acad Sci U S A. 117: 29811-29822. PMID: 33177235
- An electrochemical multicomponent reaction toward C-H tetrazolation of alkyl arenes and vicinal azidotetrazolation of alkenes. | Yu, Y., et al. 2022. Chem Sci. 13: 13851-13856. PMID: 36544744
Inhibitor of:
Phospholipase A2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FKGK 11, 500 µg | sc-223989 | 500 µg | $54.00 | |||
FKGK 11, 1 mg | sc-223989A | 1 mg | $136.00 |