FK-506-13C, D2 (Major) (CAS 1356841-89-8)
QUICK LINKS
FK-506-13C, D2 (Major) is a labeled compound that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. FK-506-13C, D2 (Major) may act to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. In analytical chemistry, FK-506-13C, D2 (Major) serves as an ideal internal standard for mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. For MS, the presence of heavier isotopes leads to distinct mass/charge (m/z) ratios. The incorporation of isotopic labels allows for precise quantification and detailed structural analysis of FK-506 in complex biological matrices. In NMR spectroscopy, the different nuclear spin properties of ^13C and ^2H compared to their more common isotopes (^12C and ^1H) provide clearer, more detailed spectra.
FK-506-13C, D2 (Major) (CAS 1356841-89-8) References
- Tacrolimus: a further update of its pharmacology and therapeutic use in the management of organ transplantation. | Plosker, GL. and Foster, RH. 2000. Drugs. 59: 323-89. PMID: 10730553
- Trough tacrolimus concentrations in the first week after kidney transplantation are related to acute rejection. | Borobia, AM., et al. 2009. Ther Drug Monit. 31: 436-42. PMID: 19494792
- Tacrolimus and the risk of solid cancers after liver transplant: a dose effect relationship. | Carenco, C., et al. 2015. Am J Transplant. 15: 678-86. PMID: 25648361
- Tacrolimus or clobetasol for treatment of oral lichen planus. | Shipley, CA. and Spivakovsky, S. 2016. Evid Based Dent. 17: 16. PMID: 27012570
- Long-Term Safety and Efficacy of Tacrolimus in Myasthenia Gravis. | Kim, YH., et al. 2019. Yonsei Med J. 60: 633-639. PMID: 31250577
- Tacrolimus and ascomycin inhibit melanoma cell growth, migration and invasion via targeting nuclear factor of activated T-cell 3. | Xiao, T., et al. 2020. Melanoma Res. 30: 325-335. PMID: 32301802
- Tacrolimus intrapatient variability in solid organ transplantation: A multiorgan perspective. | Schumacher, L., et al. 2021. Pharmacotherapy. 41: 103-118. PMID: 33131078
- Quantitation of Tacrolimus in Human Whole Blood Samples Using the MITRA Microsampling Device. | Undre, N., et al. 2021. Ther Drug Monit. 43: 364-370. PMID: 33149056
- Efficacy of Tacrolimus in Uveitis, and the Usefulness of Serum Tacrolimus Levels in Predicting Disease Control. Results from a Single Large Center. | Luis, J., et al. 2022. Ocul Immunol Inflamm. 30: 1654-1658. PMID: 34124991
- Flat Pattern Peaks of Tacrolimus Absorption and Associated Pharmacogenomic Variants in Kidney Transplantation Recipients. | Kim, SM., et al. 2022. J Korean Med Sci. 37: e33. PMID: 35132839
- Rescuing the negative effects of aging in burn wounds using tacrolimus applied via microcapillary hydrogel dressing. | White-Dzuro, CG., et al. 2022. Burns. 48: 1885-1892. PMID: 35168857
- Local delivery of tacrolimus using electrospun poly-ϵ-caprolactone nanofibres suppresses the T-cell response to peripheral nerve allografts. | Roberton, VH., et al. 2023. J Neural Eng. 20: PMID: 36538818
- Histopathological efficacy of tacrolimus in an experimental head trauma study. | Atadağ, A., et al. 2023. Ulus Travma Acil Cerrahi Derg. 29: 155-162. PMID: 36748776
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FK-506-13C, D2 (Major), 1 mg | sc-218480 | 1 mg | $1343.00 |