FIV Vif Antibody (Vif1-3): sc-65658

FIV Vif Antibody (Vif1-3) is a mouse monoclonal IgG2a antibody that detects the FIV Vif protein of FIV origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-FIV Vif antibody (Vif1-3) is available as the non-conjugated format. Feline immunodeficiency virus (FIV) is a lentivirus that poses a significant health risk to domestic cats worldwide, with five distinct subtypes identified based on variations in the viral envelope′s amino acid sequences. FIV Vif protein plays a crucial role in the viral life cycle, localizing to the nucleus and remaining essential for efficient viral replication across various cell types, including CD4+ and CD8+ T lymphocytes, B lymphocytes, and macrophages. This nuclear localization enables viral evasion of host antiviral responses, enhancing viral persistence and replication within the host. FIV transmission primarily occurs through deep bite wounds, though spread can occur via mucosal surfaces, such as those found in the mouth, rectum, and vagina. Disease progression leads to a gradual collapse of the immune system, primarily due to the infection and subsequent exhaustion of CD4+ T cells. Additionally, FIV p120 and p24 glycoproteins, associated with the viral envelope, are important for diagnosing the disease. FIV Vif protein′s ability to facilitate viral replication underscores its significance in FIV pathogenesis, making anti-FIV Vif antibody (Vif1-3) an essential tool for researchers studying this virus and its impact on feline health.

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FIV Vif Antibody (Vif1-3) References:

1. Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein.  |  Giannecchini, S., et al. 2003. J Virol. 77: 3724-33. PMID: 12610147
2. Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases.  |  Lin, YC., et al. 2003. J Virol. 77: 6589-600. PMID: 12767979
3. T cell subpopulations mediating inhibition of feline immunodeficiency virus replication in mucosally infected cats.  |  Shimojima, M., et al. 2004. Microbes Infect. 6: 265-71. PMID: 15026013
4. Feline immunodeficiency virus subtypes A, B and C and intersubtype recombinants in Ontario, Canada.  |  Reggeti, F. and Bienzle, D. 2004. J Gen Virol. 85: 1843-1852. PMID: 15218168
5. Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer.  |  Sinn, PL., et al. 2005. J Virol. 79: 12818-27. PMID: 16188984
6. Limited efficacy of an inactivated feline immunodeficiency virus vaccine.  |  Dunham, SP., et al. 2006. Vet Rec. 158: 561-2. PMID: 16632531
7. Cytokine modulation of the innate immune response in feline immunodeficiency virus-infected cats.  |  Dean, GA., et al. 2006. J Infect Dis. 193: 1520-7. PMID: 16652280
8. RNA in situ hybridization for the detection of Feline Immunodeficiency Virus in infected cells.  |  Ryan, G., et al. 2006. Southeast Asian J Trop Med Public Health. 37: 106-12. PMID: 16771221
9. Differences in feline immunodeficiency virus host cell range correlate with envelope fusogenic properties.  |  Pancino, G., et al. 1995. Virology. 206: 796-806. PMID: 7856093

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FIV Vif Antibody (Vif1-3) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FIV Vif Antibody (Vif1-3) Specifications

Alternate Product Name: FIV Vif

Product Clone Name: Vif1-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: FIV Vif

Epitope Species: FIV

Product Reactivity/Detection: Vif

Species Reactivity/Detection: FIV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FIV Vif Antibody (Vif1-3): N/A