FIV p24 Antibody (PAK3-2C1): sc-65624

FIV p24 Antibody (PAK3-2C1) is a mouse monoclonal IgG1 antibody that detects the FIV p24 protein of FIV origin by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). FIV p24 (PAK3-2C1) antibody is available as the non-conjugated format. Feline immunodeficiency virus (FIV) is a lentivirus that poses a significant health risk to domestic cats worldwide, with five distinct subtypes identified based on variations in the viral envelope′s amino acid sequences. FIV p24 plays a crucial role in the virus′s structure, forming part of the capsid that encases the viral RNA and essential enzymes, thereby protecting them during the viral life cycle. This structural integrity is vital for the virus′s ability to infect host cells and replicate, ultimately leading to the progressive immune system deterioration characteristic of FIV infection. The main transmission route of FIV is through deep bite wounds, but can also spread via mucosal surfaces, such as those found in the mouth, rectum, and vagina. Similar to human immunodeficiency virus (HIV), FIV targets various immune cells, including CD4+ and CD8+ T lymphocytes, B lymphocytes, and macrophages, resulting in the depletion and exhaustion of CD4+ cells, which are critical for maintaining a robust immune response. The glycoproteins FIV p120 and p24, which localize to the viral envelope, are instrumental in diagnosing the disease, making anti-FIV p24 antibody (PAK3-2C1) an essential tool for researchers and veterinarians working to understand and combat this viral infection.

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FIV p24 Antibody (PAK3-2C1) References:

1. A highly efficient gene delivery system derived from feline immunodeficiency virus (FIV).  |  Sauter, SL., et al. 2003. Methods Mol Med. 76: 405-32. PMID: 12526177
2. Feline immunodeficiency virus subtypes A, B and C and intersubtype recombinants in Ontario, Canada.  |  Reggeti, F. and Bienzle, D. 2004. J Gen Virol. 85: 1843-1852. PMID: 15218168
3. Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine.  |  Stevens, R., et al. 2005. Vaccine. 23: 1479-90. PMID: 15670884
4. Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer.  |  Sinn, PL., et al. 2005. J Virol. 79: 12818-27. PMID: 16188984
5. Feline immunodeficiency virus pathogenesis and development of a dual-subtype feline-immunodeficiency-virus vaccine.  |  Yamamoto, JK., et al. 2007. AIDS. 21: 547-63. PMID: 17314517
6. Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency.  |  Assogba, BD., et al. 2007. J Infect Dis. 195: 1184-8. PMID: 17357056
7. Epitope mapping of the V3 domain of feline immunodeficiency virus envelope glycoprotein by monoclonal antibodies.  |  Lombardi, S., et al. 1995. J Gen Virol. 76 (Pt 8): 1893-9. PMID: 7636470
8. Differences in feline immunodeficiency virus host cell range correlate with envelope fusogenic properties.  |  Pancino, G., et al. 1995. Virology. 206: 796-806. PMID: 7856093
9. Post-translational processing of the feline immunodeficiency virus envelope precursor protein.  |  Verschoor, EJ., et al. 1993. Virology. 193: 433-8. PMID: 8382405

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FIV p24 Antibody (PAK3-2C1) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FIV p24 Antibody (PAK3-2C1) Specifications

Alternate Product Name: FIV p24

Product Clone Name: PAK3-2C1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: FIV p24

Epitope Species: FIV

Product Reactivity/Detection: Gag p24

Species Reactivity/Detection: FIV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for FIV p24 Antibody (PAK3-2C1): N/A