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FITC-Dextran 70 (CAS 60842-46-8)

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Alternate Names:
FITC-Dextran 70 is also known as Fluorescein isothiocyanate–dextran.
Application:
FITC-Dextran 70 is a dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
CAS Number:
60842-46-8
Molecular Weight:
~70,000
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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FITC-Dextran 70 is dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals. FITC-Dextran 70 is used as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. It may also be used to study the capacity, selectivity and efficiency of encapsulation and release by drug delivery vehicles.


FITC-Dextran 70 (CAS 60842-46-8) References

  1. Dextran retention in the rat brain following release from a polymer implant.  |  Dang, W. and Saltzman, WM. 1992. Biotechnol Prog. 8: 527-32. PMID: 1282018
  2. Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules.  |  Sánchez, FA., et al. 2008. Am J Physiol Heart Circ Physiol. 295: H1642-8. PMID: 18708444
  3. Concurrent elution of calcium phosphate and macromolecules from alginate/chitosan hydrogel coatings.  |  Peng, P., et al. 2008. Biointerphases. 3: 105-16. PMID: 20408707
  4. In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules.  |  Parmentier, J., et al. 2010. Eur J Pharm Biopharm. 76: 394-403. PMID: 20849953
  5. Functional significance of cytosolic endothelial nitric-oxide synthase (eNOS): regulation of hyperpermeability.  |  Sánchez, FA., et al. 2011. J Biol Chem. 286: 30409-30414. PMID: 21757745
  6. Hydroxyethyl starch-based polymers for the controlled release of biomacromolecules from hydrogel microspheres.  |  Wöhl-Bruhn, S., et al. 2012. Eur J Pharm Biopharm. 81: 573-81. PMID: 22579731
  7. Biomolecule delivery into canola protoplasts by centrifuging cells with microbubbles.  |  He, C., et al. 2013. FEBS Lett. 587: 285-90. PMID: 23262220
  8. High Efficiency Molecular Delivery with Sequential Low-Energy Sonoporation Bursts.  |  Song, KH., et al. 2015. Theranostics. 5: 1419-27. PMID: 26681986
  9. Loading Efficiency of Polymersomes with Contrast Agents and their Intracellular Delivery: Quantum Dots Versus Organic Dyes.  |  Semkova, S., et al. 2018. Anticancer Res. 38: 825-831. PMID: 29374708
  10. Identification and local manipulation of bone marrow vasculature during intravital imaging.  |  Morikawa, T., et al. 2020. Sci Rep. 10: 6422. PMID: 32286470
  11. VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation.  |  Lou, X., et al. 2021. Oxid Med Cell Longev. 2021: 9397960. PMID: 34552687
  12. Aqueous humor dynamics in experimental iridocyclitis.  |  Toris, CB. and Pederson, JE. 1987. Invest Ophthalmol Vis Sci. 28: 477-81. PMID: 3557859
  13. New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1.  |  Ye, L., et al. 2022. Stem Cell Res Ther. 13: 496. PMID: 36209115
  14. Transient analysis of macromolecular transport across microvascular wall and into interstitium.  |  Kim, D., et al. 1993. Am J Physiol. 265: H993-9. PMID: 7692749
  15. Nitric oxide and cGMP regulate endothelial permeability and F-actin distribution in hydrogen peroxide-treated endothelial cells.  |  Liu, SM. and Sundqvist, T. 1997. Exp Cell Res. 235: 238-44. PMID: 9281373

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

FITC-Dextran 70, 100 mg

sc-263323
100 mg
$140.00

FITC-Dextran 70, 500 mg

sc-263323A
500 mg
$446.00

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, FITC I dextran (CAS 60842-46-8), should be shipped ambient.
Answered by: Chemical Support 1
Date published: 2017-04-04
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Rated 5 out of 5 by from Various publications cite the use of FITCVarious publications cite the use of FITC I dextran (Fluorescein isothiocyanate I dextran; FITC-Dextran 70; FITC-Dextran 70) for use as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. FITC I dextran may be used to study the capacity, selectivity and efficiency of encapsulation and release by drug delivery vehicles. -SCBT Publication Review
Date published: 2015-03-15
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FITC-Dextran 70 is rated 5.0 out of 5 by 1.
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