Molecular structure of FIPI hydrochloride, CAS Number: 1781834-93-2
FIPI hydrochloride (CAS 1781834-93-2)
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Alternate Names:
4-Fluoro-N-(2-(4-(5-fluoro-1H-indol-1-yl)piperidin-1-yl)ethyl)benzamide, 5-Fluoro-2-indolyl des-chlorohalopemide hydrochloride
Application:
FIPI hydrochloride is a potent Phospholipase D inhibitor
CAS Number:
1781834-93-2
Purity:
≥98%
Molecular Weight:
457.93
Molecular Formula:
C23H24FN5O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FIPI hydrochloride is a potent inhibitor of PLD (phospholipase D) specifically PLD 1 and PLD 2. Phospholipase D catalyzes the hydrolysis of phosphatidylcholine to form phosphatidic acid which is essential in many biological processes such as Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. Studies suggest that FIPI hydrochloride hydrate can block the production of phosphatidic acid with subnanomolar potency. Alternate studies show that FIPI hydrochloride hydrate inhibits the O2- and cell migration in rat neutrophils. It has been observed that FIPI hydrochloride hydrate can regulate F-actin cytoskeleton rearrangement.
FIPI hydrochloride (CAS 1781834-93-2) References
- 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. | Su, W., et al. 2009. Mol Pharmacol. 75: 437-46. PMID: 19064628
- Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils. | Chang, LC., et al. 2011. Biochem Pharmacol. 81: 269-78. PMID: 20965153
- Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells. | Patel, RB., et al. 2011. Int J Toxicol. 30: 69-90. PMID: 21131602
- Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. | Pastor, A., et al. 2014. J Lipid Res. 55: 966-77. PMID: 24610889
- RhoH is a negative regulator of eosinophilopoiesis. | Stoeckle, C., et al. 2016. Cell Death Differ. 23: 1961-1972. PMID: 27740624
- Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction. | Hakuno, D., et al. 2018. Sci Rep. 8: 16749. PMID: 30425314
Inhibitor of:
PC-PLD1, and PC-PLD2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FIPI hydrochloride, 5 mg | sc-300694 | 5 mg | $258.00 |