FIPI CAS: 939055-18-2
MF: C23H24FN5O2
MW: 421.5
A cell-permeable, PLD1/2 inhibitor.

FIPI (CAS 939055-18-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 111ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 5-Fluoro-2-Indolyl des-Chlorohalopemide
Application: A cell-permeable, PLD1/2 inhibitor
CAS Number: 939055-18-2
Purity: ≥98%
Molecular Weight: 421.5
Molecular Formula: C23H24FN5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

FIPI is a cell-permeable, PC-PLD1/2 (PLD1/2) inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. FIPI is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM.


References

1 Su, W., Yeku, O., Olepu, S., et al. 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol 75(3) 437-446 (2009). 2 Monovich, L., Mugrage, B., Quadros, E., et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett 17 2310-2311 (2007).

Physical State :
Solid
Solubility :
Soluble in 1:9 DMF:PBS(ph7.2) (~0.1 mg/ml), ethanol (~0.25 mg/ml), DMSO (~20 mg/ml), and DMF (~20 mg/ml).
Storage :
Store at -20° C
Melting Point :
295.54° C (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D ~1.66 (Predicted)
IC50 :
Phospholipase D1: IC50 = 1 nM (human); Phospholipase D2: IC50 = 17 nM (human)
pK Values :
pKa: 12.04 (Predicted), pKb: 8.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16739265
MDL Number :
MFCD18382115
SMILES :
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

FIPI  Product Citations

See how others have used FIPI. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28819302  Westphal, N. et al. 2017. Sci Rep. 7: 8622.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 117ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.