Filorexant (CAS 1088991-73-4)
Alternate Names:
MK 6096; MK6096; MK-6096
CAS Number:
1088991-73-4
Molecular Weight:
420.50
Molecular Formula:
C24H25FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Filorexant (CAS 1088991-73-4) References
- Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. | Coleman, PJ., et al. 2012. ChemMedChem. 7: 415-24, 337. PMID: 22307992
- Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats. | Fox, SV., et al. 2013. Neuropsychopharmacology. 38: 2401-8. PMID: 23722242
- Distinct effects of IPSU and suvorexant on mouse sleep architecture. | Hoyer, D., et al. 2013. Front Neurosci. 7: 235. PMID: 24368893
- Kinetic properties of 'dual' orexin receptor antagonists at OX1R and OX2R orexin receptors. | Callander, GE., et al. 2013. Front Neurosci. 7: 230. PMID: 24376396
- Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant. | Kuduk, SD., et al. 2014. Bioorg Med Chem Lett. 24: 1784-9. PMID: 24630562
- Unusual pyrimidine participation: efficient stereoselective synthesis of potent dual orexin receptor antagonist MK-6096. | Chung, JY., et al. 2014. Org Lett. 16: 5890-3. PMID: 25365229
- Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant. | Raheem, IT., et al. 2015. Bioorg Med Chem Lett. 25: 444-50. PMID: 25577040
- Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties. | Kuduk, SD., et al. 2015. Bioorg Med Chem Lett. 25: 2488-92. PMID: 25981685
- Methyl-containing pharmaceuticals: Methylation in drug design. | Sun, S. and Fu, J. 2018. Bioorg Med Chem Lett. 28: 3283-3289. PMID: 30243589
- One-Step Regio- and Stereoselective Electrochemical Synthesis of Orexin Receptor Antagonist Oxidative Metabolites. | Yao, H., et al. 2022. J Org Chem. 87: 15011-15021. PMID: 36322780
Inhibitor of:
Orexin R-1, Orexin R-2, and QRFP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Filorexant, 10 mg | sc-507325 | 10 mg | $380.00 |