Molecular structure of Filgotinib, CAS Number: 1206161-97-8
Filgotinib (CAS 1206161-97-8)
Alternate Names:
N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-]pyridin-2-yl]-cyclopropanecarboxamide
CAS Number:
1206161-97-8
Molecular Weight:
425.5
Molecular Formula:
C21H23N5O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Filgotinib (CAS 1206161-97-8) References
- Filgotinib for the treatment of Crohn's disease. | Labetoulle, R., et al. 2018. Expert Opin Investig Drugs. 27: 295-300. PMID: 29448862
- Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial. | Genovese, MC., et al. 2019. JAMA. 322: 315-325. PMID: 31334793
- Filgotinib, a novel JAK1-preferential inhibitor for the treatment of rheumatoid arthritis: An overview from clinical trials. | Tanaka, Y., et al. 2022. Mod Rheumatol. 32: 1-11. PMID: 33740386
- JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib. | Traves, PG., et al. 2021. Ann Rheum Dis. 80: 865-875. PMID: 33741556
- Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial. | Feagan, BG., et al. 2021. Lancet. 397: 2372-2384. PMID: 34090625
- Filgotinib in Rheumatoid Arthritis: A Profile of Its Use. | Kim, ES. and Keam, SJ. 2021. Clin Drug Investig. 41: 741-749. PMID: 34304373
- Evaluating filgotinib for the treatment of rheumatoid arthritis. | Richez, C. and Truchetet, ME. 2021. Expert Opin Pharmacother. 22: 2435-2444. PMID: 34402699
- Filgotinib for moderately to severely active ulcerative colitis. | Mannucci, A., et al. 2022. Expert Rev Gastroenterol Hepatol. 16: 927-940. PMID: 36278878
- Filgotinib in rheumatoid arthritis. | Westhovens, R. 2023. Expert Rev Clin Immunol. 19: 135-144. PMID: 36396615
Inhibitor of:
β-defensin 40, C6orf182_2410017P07Rik, CD2BP2, GBP3, IFN-α/βRα, IFN-α/βRβ, IFN-α13, IFN-α2, IFN-α6, IFN-β, IL-10Rβ, IL-15, IL-1ra, IL-20Rβ, IL-21R, IL-22Rα2, IL-6, Interferon (IFN), Interferon (IFN) Receptor, JAK1, JAKMIP3, JFC1, MsrB2, NALP9A, Olr184, Olr559, RT1-Db1, and SOCS-5.Activator of:
SPPL2b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Filgotinib, 10 mg | sc-507393 | 10 mg | $150.00 |