Molecular structure of Fibronectin Inhibitor, CAS Number: 91037-65-9
Fibronectin Inhibitor Inhibitor (CAS 91037-65-9)
See product citations (3)
Alternate Names:
Fibronectin tetrapeptide; H-Arg-Gly-Asp-Ser-OH
Application:
Fibronectin Inhibitor is a tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding
CAS Number:
91037-65-9
Purity:
≥97%
Molecular Weight:
433.40
Molecular Formula:
C15H27N7O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fibronectin Inhibitor is a tetrapeptide which supports fibroblast attachment and inhibits fibronectin binding to platelets. Also an integrin binding sequence that inhibits integrin receptor function. May decrease systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. May promote cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. Known to be a target sequence for syphilis spirochete adherence.
Fibronectin Inhibitor Inhibitor (CAS 91037-65-9) References
- Matrix regulation of skeletal cell apoptosis II: role of Arg-Gly-Asp-containing peptides. | Perlot, RL., et al. 2002. J Bone Miner Res. 17: 66-76. PMID: 11771671
- Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. | Grigoriou, V., et al. 2005. J Biol Chem. 280: 1733-9. PMID: 15522882
- Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. | Moon, C., et al. 2009. Respir Res. 10: 18. PMID: 19272161
- Matrix metalloproteinase-2-deficient fibroblasts exhibit an alteration in the fibrotic response to connective tissue growth factor/CCN2 because of an increase in the levels of endogenous fibronectin. | Droppelmann, CA., et al. 2009. J Biol Chem. 284: 13551-13561. PMID: 19276073
- Fibronectin is an important regulator of flow-induced vascular remodeling. | Chiang, HY., et al. 2009. Arterioscler Thromb Vasc Biol. 29: 1074-9. PMID: 19407246
- Role of fibronectin in the adhesion of Acinetobacter baumannii to host cells. | Smani, Y., et al. 2012. PLoS One. 7: e33073. PMID: 22514602
- Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin. | Haverstick, DM., et al. 1985. Blood. 66: 946-52. PMID: 3876125
- Fibronectin tetrapeptide is target for syphilis spirochete cytadherence. | Thomas, DD., et al. 1985. J Exp Med. 162: 1715-9. PMID: 3903025
- Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion. | Ginsberg, M., et al. 1985. J Biol Chem. 260: 3931-6. PMID: 3980461
- Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | Pierschbacher, MD. and Ruoslahti, E. Nature. 309: 30-3. PMID: 6325925
Inhibitor of:
Integrin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fibronectin Inhibitor, 25 mg | sc-202156 | 25 mg | $194.00 |