Fibrillarin Antibody (F-6): sc-166000
- Fibrillarin Antibody (F-6) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 61-200 of Fibrillarin of human origin
- recommended for detection of Fibrillarin of mouse, rat and human origin by WB, IP, IF and ELISA
- See Fibrillarin (G-8): sc-374022 for Fibrillarin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Fibrillarin Antibody (F-6) for WB applications. These reagents are now offered in bundles with Fibrillarin Antibody (F-6) (see ordering information below).
QUICK LINKS
SEE ALSO...
Fibrillarin Antibody (F-6) is a mouse monoclonal IgG2a antibody that detects fibrillarin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fibrillarin is a crucial nonhistone protein predominantly localized in the fibrillar region of the nucleolus, specifically within the dense fibrillar and fibrillar center regions, where fibrillarin plays a vital role in the processing of ribosomal RNA (rRNA) transcripts. This localization is significant as fibrillarin′s essential function in ribosome biogenesis is critical for protein synthesis in all living cells. Notably, fibrillarin contains an RNA-binding domain and an RNP consensus sequence, which facilitate fibrillarin′s interaction with U3 small nucleolar RNA, further emphasizing fibrillarin′s role in rRNA processing. Additionally, during the cell cycle, fibrillarin serves as an early marker for the formation of the nucleolus in telophase, highlighting fibrillarin′s dynamic involvement in cellular organization and function. Anti-fibrillarin antibody (F-6) is an invaluable tool for researchers studying nucleolar dynamics, rRNA processing, and related cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fibrillarin Antibody (F-6) References:
- Fibrillarin from Archaea to human. | Rodriguez-Corona, U., et al. 2015. Biol Cell. 107: 159-74. PMID: 25772805
- Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions. | Shubina, MY., et al. 2016. Biochemistry (Mosc). 81: 941-50. PMID: 27682166
- Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance. | El Hassouni, B., et al. 2019. Curr Med Chem. 26: 6020-6032. PMID: 30501594
- Plant viral proteins and fibrillarin: the link to complete the infective cycle. | Decle-Carrasco, S., et al. 2021. Mol Biol Rep. 48: 4677-4686. PMID: 34036480
- Fibrillarin antibodies in systemic sclerosis. | Lee, A. 2022. Arch Rheumatol. 37: 311-312. PMID: 36017207
- A cell-based assay for detection of anti-fibrillarin autoantibodies with performance equivalent to immunoprecipitation. | Keppeke, GD., et al. 2022. Front Immunol. 13: 1011110. PMID: 36225928
- Current research on viral proteins that interact with fibrillarin. | Decle-Carrasco, S., et al. 2023. Mol Biol Rep. 50: 4631-4643. PMID: 36928641
- Dotting Out AML by Targeting Fibrillarin. | Luo, H. and Kharas, MG. 2024. Cancer Res. 84: 2759-2760. PMID: 38924716
- Fibrillarin reprograms glucose metabolism by driving the enhancer-mediated transcription of PFKFB4 in liver cancer. | Liu, Y., et al. 2024. Cancer Lett. 602: 217190. PMID: 39182558
- Advances in the structure and function of the nucleolar protein fibrillarin. | Zhang, X., et al. 2024. Front Cell Dev Biol. 12: 1494631. PMID: 39605984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fibrillarin Antibody (F-6) | sc-166000 | 200 µg/ml | $322.00 | |||
Fibrillarin Antibody (F-6): m-IgG Fc BP-HRP Bundle | sc-539985 | 200 µg Ab; 10 µg BP | $361.00 | |||
Fibrillarin Antibody (F-6): m-IgG2a BP-HRP Bundle | sc-546830 | 200 µg Ab; 10 µg BP | $361.00 |