FHOD1 Antibody (B-6): sc-365433
- FHOD1 Antibody (B-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 34-110 mapping near the N-terminus of FHOD1 of human origin
- recommended for detection of FHOD1 of human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FHOD1 Antibody (B-6) for WB applications. These reagents are now offered in bundles with FHOD1 Antibody (B-6) (see ordering information below).
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FHOD1 Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects FHOD1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FHOD1, a member of the formin family, is essential for cytoskeletal dynamics, particularly in the assembly of actin filaments, which are critical for various cellular processes including cell migration, shape maintenance, and division. FHOD1 is predominantly located in the cytoplasm, where FHOD1 plays a pivotal role in organizing actin stress fibers in response to signaling pathways, particularly the Rho-ROCK cascade. This localization enables FHOD1 to effectively regulate cytoskeletal architecture, thereby influencing cellular responses to external stimuli and contributing to overall tissue structure during development. Aberrations in FHOD1 function can lead to developmental syndromes, highlighting FHOD1′s importance in normal limb development and cellular homeostasis. Anti-FHOD1 antibody (B-6) serves as an invaluable tool for researchers investigating mechanisms of cytoskeletal regulation and implications in developmental biology and disease.
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FHOD1 Antibody (B-6) References:
- FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion. | Gardberg, M., et al. 2013. PLoS One. 8: e74923. PMID: 24086398
- FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers. | Schulze, N., et al. 2014. J Cell Sci. 127: 1379-93. PMID: 24481812
- FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement. | Kutscheidt, S., et al. 2014. Nat Cell Biol. 16: 708-15. PMID: 24880667
- Active FHOD1 promotes the formation of functional actin stress fibers. | Shi, X., et al. 2019. Biochem J. 476: 2953-2963. PMID: 31657439
- Downregulation of FHOD1 Inhibits Metastatic Potential in A549 Cells. | Hałas-Wiśniewska, M., et al. 2021. Cancer Manag Res. 13: 91-106. PMID: 33447082
- Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins. | Lim, SM., et al. 2021. Structure. 29: 540-552.e5. PMID: 33472039
- FHOD1 and FMNL1 formin proteins in intestinal gastric cancer: correlation with tumor-infiltrating T lymphocytes and molecular subtypes. | Mansuri, N., et al. 2021. Gastric Cancer. 24: 1254-1263. PMID: 34115237
- FHOD1 is upregulated in gastric cancer and promotes the proliferation and invasion of gastric cancer cells. | Jiang, C., et al. 2021. Oncol Lett. 22: 712. PMID: 34457067
- FHOD1 is upregulated in glioma cells and attenuates ferroptosis of glioma cells by targeting HSPB1 signaling. | Zhang, F., et al. 2023. CNS Neurosci Ther. 29: 3351-3363. PMID: 37211949
- Novel signaling axis of FHOD1-RNF213-Col1α/Col3α in the pathogenesis of hypertension-induced tunica media thickening. | Chen, Y., et al. 2023. J Mol Cell Cardiol. 182: 57-72. PMID: 37482037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FHOD1 Antibody (B-6) | sc-365433 | 200 µg/ml | $322.00 | |||
FHOD1 Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-535195 | 200 µg Ab; 40 µg BP | $361.00 | |||
FHOD1 Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-538880 | 200 µg Ab; 20 µg BP | $361.00 |