FHOD1 Inhibitors
The chemical class known as FHOD1 Inhibitors comprises a range of small molecules and compounds designed to selectively interfere with the function of Formin homology 2 domain-containing protein 1 (FHOD1). FHOD1 is a critical regulator of actin cytoskeleton dynamics, playing an essential role in processes such as cell migration and tissue development. FHOD1 Inhibitors are meticulously developed to target specific binding sites or domains within FHOD1, thereby modulating its interaction with actin filaments and altering actin-related cellular processes. By perturbing FHOD1's activity, these inhibitors offer a means to elucidate the intricate mechanisms governing actin cytoskeleton remodeling and its impact on cellular functions.
The discovery and characterization of FHOD1 Inhibitors contribute to advancing our understanding of fundamental cellular processes and molecular interactions, potentially leading to novel insights in the field of cell biology. Ongoing research into the mechanisms of action and broader implications of FHOD1 Inhibitors continue to shed light on the intricacies of actin dynamics and its role in various physiological and pathological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CCG 203971 | 1443437-74-8 | sc-507360 | 10 mg | $89.00 | ||
A small molecule inhibitor that targets the actin-binding FH2 domain of FHOD1, potentially disrupting its role in actin filament assembly and dynamics. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
This compound has been reported to inhibit the actin-binding properties of FHOD1, thereby affecting actin cytoskeleton remodeling. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
A widely used FHOD1 inhibitor, SMIFH2 specifically targets the FH2 domain, impeding actin nucleation and elongation by FHOD1. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Although primarily developed as an inhibitor of Arp2/3 complex-mediated actin nucleation, CK-666 has been found to also influence FHOD1-dependent actin dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
While mainly known as a Rho-associated protein kinase (ROCK) inhibitor, Y-27632 can indirectly affect FHOD1 activity through its impact on Rho signaling and actin dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin compounds disrupt actin polymerization, indirectly affecting FHOD1's role in actin cytoskeleton organization. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Primarily recognized as a myosin II inhibitor, blebbistatin can influence FHOD1-related processes through its effects on actomyosin contractility. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
A toxin that binds and stabilizes actin filaments, indirectly influencing FHOD1's actin regulatory functions. | ||||||