Date published: 2025-10-2

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FGIN-1-27 (CAS 142720-24-9)

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Application:
FGIN-1-27 is a potent inositol monophosphatase inhibitor
CAS Number:
142720-24-9
Purity:
>98%
Molecular Weight:
436.6
Molecular Formula:
C28H37FN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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FGIN-1-27 is a specific and high affinity agonist of mitochondrial benzodiazepine receptors (PBR).


FGIN-1-27 (CAS 142720-24-9) References

  1. Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.  |  Bitran, D., et al. 2000. Psychopharmacology (Berl). 151: 64-71. PMID: 10958118
  2. Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43.  |  Guillon, J., et al. 2001. J Pharm Pharmacol. 53: 1561-8. PMID: 11732760
  3. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells.  |  Sutter, AP., et al. 2002. Int J Cancer. 102: 318-27. PMID: 12402299
  4. 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).  |  Romeo, E., et al. 1992. J Pharmacol Exp Ther. 262: 971-8. PMID: 1326631
  5. In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters.  |  Petralia, SM. and Frye, CA. 2005. Psychopharmacology (Berl). 178: 174-82. PMID: 15338106
  6. Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.  |  Opatz, T. and Ferenc, D. 2006. Org Lett. 8: 4473-5. PMID: 16986928
  7. Identification of three antiviral inhibitors against Japanese encephalitis virus from library of pharmacologically active compounds 1280.  |  Fang, J., et al. 2013. PLoS One. 8: e78425. PMID: 24348901
  8. In vitro effect of FGIN-1-27, a ligand to 18 kDa mitochondrial translocator protein, in human osteoblast-like cells.  |  Rosenberg, N., et al. 2014. J Bioenerg Biomembr. 46: 197-204. PMID: 24532136
  9. FGIN-1-27, an agonist at translocator protein 18 kDa (TSPO), produces anti-anxiety and anti-panic effects in non-mammalian models.  |  Lima-Maximino, MG., et al. 2018. Pharmacol Biochem Behav. 171: 66-73. PMID: 29698632
  10. Acute effects of the translocator protein drug ligand FGIN-1-27 on serum testosterone and luteinizing hormone levels in male Sprague-Dawley rats†.  |  Chen, F., et al. 2019. Biol Reprod. 100: 824-832. PMID: 30299464
  11. Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells.  |  Singh, A., et al. 2020. Sci Rep. 10: 3766. PMID: 32111885
  12. TSPO ligand FGIN-1-27 controls priapism in sickle cell mice via endogenous testosterone production.  |  Musicki, B., et al. 2021. J Cell Physiol. 236: 3073-3082. PMID: 32974910
  13. FGIN-1-27 Inhibits Melanogenesis by Regulating Protein Kinase A/cAMP-Responsive Element-Binding, Protein Kinase C-β, and Mitogen-Activated Protein Kinase Pathways.  |  Lv, J., et al. 2020. Front Pharmacol. 11: 602889. PMID: 33390991
  14. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.  |  Atack, JR., et al. 1993. J Neurochem. 60: 652-8. PMID: 8380439
  15. Subsensitivity to mitochondrial diazepam binding inhibitor receptor agonist FGIN-1-27-induced antiseizure effect in diazepam-withdrawn mice.  |  Tsuda, M., et al. 1998. Life Sci. 62: PL213-7. PMID: 9570345

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

FGIN-1-27, 5 mg

sc-202611
5 mg
$39.00

FGIN-1-27, 25 mg

sc-202611A
25 mg
$135.00