FGF-BP Antibody (4912Z): sc-73991

FGF-BP Antibody (4912Z) is a mouse monoclonal IgG1 antibody that detects FGF-BP protein of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-FGF-BP antibody (4912Z) is available as the non-conjugated format. Fibroblast growth factor binding protein, or FGF-BP, plays a crucial role in regulating fibroblast growth factors (FGFs), which are a family of over 20 distinct proteins essential for various biological processes, including development, tissue homeostasis, angiogenesis, and cancer progression. FGF-BP is a secreted protein that binds to FGF-1 and FGF-2, facilitating mobilization and activation from the extracellular matrix. FGF-BP is typically expressed at low levels in normal adult human tissues, but expression is significantly elevated in various tumors, such as head, neck, skin, cervical, and lung squamous cell carcinomas. Up-regulation of FGF-BP during early phases of tumorigenesis highlights a critical role in angiogenesis, serving as an angiogenic switch molecule that tumors exploit for growth and progression. Expression of FGF-BP is regulated by key promoter elements, including C/EBP and AP-1, which respond to serum and epidermal growth factor, respectively. This intricate regulation underscores FGF-BP′s importance in both normal physiology and pathological conditions, making FGF-BP monoclonal antibody (4912Z) a valuable tool for researchers studying cancer biology and angiogenesis.

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FGF-BP Antibody (4912Z) References:

1. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core.  |  Mongiat, M., et al. 2001. J Biol Chem. 276: 10263-71. PMID: 11148217
2. An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release.  |  Aigner, A., et al. 2001. Int J Cancer. 92: 510-7. PMID: 11304685
3. Serum induction of the fibroblast growth factor-binding protein (FGF-BP) is mediated through ERK and p38 MAP kinase activation and C/EBP-regulated transcription.  |  Harris, VK., et al. 2001. Oncogene. 20: 1730-8. PMID: 11313920
4. Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein.  |  Tassi, E., et al. 2001. J Biol Chem. 276: 40247-53. PMID: 11509569
5. The human papillomavirus (HPV) 16 E6 oncoprotein leads to an increase in gene expression of the angiogenic switch molecule FGF-BP in non-immortalized human keratinocytes.  |  Stöppler, H., et al. 2001. Oncogene. 20: 7430-6. PMID: 11704874
6. Ribozyme-targeting of a secreted FGF-binding protein (FGF-BP) inhibits proliferation of prostate cancer cells in vitro and in vivo.  |  Aigner, A., et al. 2002. Oncogene. 21: 5733-42. PMID: 12173043
7. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.  |  Beer, HD., et al. 2005. Oncogene. 24: 5269-77. PMID: 15806171
8. The fibroblast growth factor-binding protein FGF-BP.  |  Abuharbeid, S., et al. 2006. Int J Biochem Cell Biol. 38: 1463-8. PMID: 16324873
9. Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma.  |  Schulze, D., et al. 2011. Mol Cancer. 10: 144. PMID: 22111880
10. Ghrelin Ameliorates Traumatic Brain Injury by Down-Regulating bFGF and FGF-BP.  |  Shao, X., et al. 2018. Front Neurosci. 12: 445. PMID: 30026681
11. Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis.  |  Kurtz, A., et al. 1997. Oncogene. 14: 2671-81. PMID: 9178765
12. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.  |  Czubayko, F., et al. 1997. Nat Med. 3: 1137-40. PMID: 9334727

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FGF-BP Antibody (4912Z) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FGF-BP Antibody (4912Z) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FGF-BP Antibody (4912Z) Specifications

Alternate Product Name: FGF-BP

Product Clone Name: 4912Z

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: FGF-BP

Epitope Species: human

Product Reactivity/Detection: FGF-BP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FGF-BP Antibody (4912Z): N/A