Molecular structure of Fexofenadine HCl, CAS Number: 153439-40-8
Fexofenadine HCl (CAS 153439-40-8)
Alternate Names:
MDL 16455
Application:
Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist
CAS Number:
153439-40-8
Purity:
≥99%
Molecular Weight:
538.12
Molecular Formula:
C32H39NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fexofenadine HCl, a metabolite of terfenadine, has demonstrated to be a nonsedating Histamine H1 receptor antagonist. Mechanistic studies have reported that high concentrations of this compound can inhibit Cox-1 activity while low concentrations of Fexofenadine HCl inhibits Cox-2 activity. In one study, Fexofenadine HCl was found to inhibit the release of histamine, leukotrienes, and other inflammatory mediators. In another study, Fexofenadine HCl reduced the production of pro-inflammatory cytokines.
Fexofenadine HCl (CAS 153439-40-8) References
- Cardiovascular safety of fexofenadine HCl. | Pratt, CM., et al. 1999. Am J Cardiol. 83: 1451-4. PMID: 10335761
- Variations among non-sedating antihistamines: are there real differences? | Mattila, MJ. and Paakkari, I. 1999. Eur J Clin Pharmacol. 55: 85-93. PMID: 10335901
- Hepatic disposition of fexofenadine: influence of the transport inhibitors erythromycin and dibromosulphothalein. | Milne, RW., et al. 2000. Pharm Res. 17: 1511-5. PMID: 11303961
- The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. | Watanabe, N., et al. 2004. Int Immunopharmacol. 4: 367-75. PMID: 15037214
- Differential effects of fexofenadine on arachidonic acid metabolism in cultured human monocytes. | Juergens, UR., et al. 2006. Pharmacology. 76: 40-5. PMID: 16254456
- Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. | Gillard, M. and Chatelain, P. 2006. Eur J Pharmacol. 530: 205-14. PMID: 16388798
- Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer. | Lin, H., et al. 2007. Int J Pharm. 330: 23-31. PMID: 16997520
- New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro. | Juergens, UR., et al. 2006. Pharmacology. 78: 129-35. PMID: 17016062
- Fast Dissolving Tablets of Fexofenadine HCl by Effervescent Method. | Nagendrakumar, D., et al. 2009. Indian J Pharm Sci. 71: 116-9. PMID: 20336204
- Spectrofluorimetric determination of etodolac, moxepril HCl and fexofenadine HCl using europium sensitized fluorescence in bulk and pharmaceutical preparations. | el-Hay, SS., et al. 2012. J Fluoresc. 22: 247-52. PMID: 21853256
- Identification and Characterization of an Oxidative Degradation Product of Fexofenadine, Development and Validation of a Stability-Indicating RP-UPLC Method for the Estimation of Process Related Impurities and Degradation Products of Fexofenadine in Pharmaceutical Formulations. | Vaghela, B., et al. 2012. Sci Pharm. 80: 295-309. PMID: 22896817
- Simultaneous quantitation of Ofloxacin, Fexofenadine HCl and Diclofenac Potassium in affixed dose combinative formulation by HPLC-UV method. | Salam, FA., et al. 2015. Pak J Pharm Sci. 28: 1979-84. PMID: 26639475
- Design, characterization and in vitro evaluation of HPMC K100 M CR loaded Fexofenadine HCl microspheres. | Arefin, P., et al. 2016. Springerplus. 5: 691. PMID: 27350925
- Effect of fexofenadine hydrochloride on allergic rhinitis aggravated by air pollutants. | Ellis, AK., et al. 2021. ERJ Open Res. 7: PMID: 33834054
- Efficacy of Naproxen/Fexofenadine (SJP-003) in the Prevention of Side Effects of Influenza Vaccination: Four Case Studies. | Kiani, P., et al. 2022. Clin Pract. 12: 734-737. PMID: 36136870
Inhibitor of:
Cox-2, and Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fexofenadine HCl, 10 mg | sc-203047 | 10 mg | $129.00 | |||
Fexofenadine HCl, 50 mg | sc-203047A | 50 mg | $413.00 |