Molecular structure of Fexofenadine, CAS Number: 83799-24-0
Fexofenadine (CAS 83799-24-0)
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Alternate Names:
4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-benzene-acetic Acid; Terfenadine Acid Metabolite
Application:
Fexofenadine is A metabolite of of terfenadine, a H1-Histamine receptor antagonist
CAS Number:
83799-24-0
Molecular Weight:
501.66
Molecular Formula:
C32H39NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fexofenadine, a long-lasting selective histamine H1 receptor antagonist, exhibits anti-inflammatory properties. It selectively competes with histamine at peripheral H1 receptors in the gastrointestinal tract, blood vessels, and bronchial smooth muscle. Researchers utilize this compound to explore the regulatory processes of histamine receptors and the cellular release of various chemical mediators. The compound′s interactions and effects on mast cell stability are of particular interest in immunological research, providing insights into cellular defense mechanisms.
Fexofenadine (CAS 83799-24-0) References
- Fexofenadine does not affect omeprazole pharmacokinetics: both are putative P-glycoprotein substrates. | Takahata, T., et al. 2004. Basic Clin Pharmacol Toxicol. 94: 252-6. PMID: 15125696
- Fexofenadine in horses: pharmacokinetics, pharmacodynamics and effect of ivermectin pretreatment. | Olsén, L., et al. 2006. J Vet Pharmacol Ther. 29: 129-35. PMID: 16515667
- Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. | Smith, SM. and Gums, JG. 2009. Expert Opin Drug Metab Toxicol. 5: 813-22. PMID: 19545214
- Regional absorption of fexofenadine in rat intestine. | MacLean, C., et al. 2010. Eur J Pharm Sci. 41: 670-4. PMID: 20869437
- Efficacy of fexofenadine in isolated rat tracheas. | Lai, WS., et al. 2013. Rhinology. 51: 376-80. PMID: 24260772
- Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice. | Koh, SJ., et al. 2015. J Pharmacol Exp Ther. 352: 455-61. PMID: 25538104
- Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy. | Matsubara, R., et al. 2017. Int J Mol Sci. 18: PMID: 28672829
- Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1. | Medwid, S., et al. 2019. Drug Metab Dispos. 47: 832-842. PMID: 31123035
- Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis. | Liu, R., et al. 2019. Ann Rheum Dis. 78: 1524-1535. PMID: 31302596
- Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials. | Huang, CZ., et al. 2019. BMC Pharmacol Toxicol. 20: 72. PMID: 31783781
- Targeting spinal microglia with fexofenadine-loaded nanoparticles prolongs pain relief in a rat model of neuropathic pain. | Tran, Q., et al. 2022. Nanomedicine. 44: 102576. PMID: 35714922
- Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants. | Han, H., et al. 2022. Drug Metab Pharmacokinet. 47: 100470. PMID: 36116173
- Fexofenadine protects against lipopolysaccharide-induced acute lung injury by targeting cytosolic phospholipase A2. | Chen, Y., et al. 2023. Int Immunopharmacol. 116: 109637. PMID: 36764283
Inhibitor of:
Exportin (XPO), H2RSP, Histamine, Histamine H1 Receptor, OATP-D, OATP-E, OATP-F, OATP-J, Oatp4, Olfr251, Olfr948, Olfr954, Olfr963, Olr14, Siglec-8, SLC22A29, and Tracheobronchial Mucin.Activator of:
EG435927, Fc ε RIβ, MATE2, Oatp2, OATP2A1, and Serglycin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fexofenadine, 100 mg | sc-218475 | 100 mg | $298.00 |