FeTPPS (CAS 90384-82-0)
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FeTPPS (Fluorescent-tagged Thiol-Protected Proteolytic Substrate) is an innovative peptide-based fluorescent substrate poised to revolutionize proteomic research. Designed with precision, this substrate empowers researchers to accurately assess proteolytic activity in diverse biological systems. FeTPPS stands out as a highly selective and sensitive fluorescent substrate, facilitating the measurement of protease activity in both in vitro and in vivo models. The versatility of FeTPPS extends to various scientific research applications. It has been extensively employed to gauge protease activity, shedding light on their involvement in signal transduction pathways and the impact of drugs on protease activity. Furthermore, FeTPPS has proven invaluable in exploring the effects of mutations on proteases and investigating the influence of proteases on protein folding and stability. FeTPPS operates by binding to the active site of a protease, triggering the activation of the attached fluorescent dye. This activation generates a distinct fluorescence signal that serves as a quantifiable indicator of protease activity. Leveraging the exceptional sensitivity of FeTPPS, protease activity can be reliably detected across a broad range of biological systems, encompassing cells and tissues.
FeTPPS (CAS 90384-82-0) References
- Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats. | Thiyagarajan, M., et al. 2004. Br J Pharmacol. 142: 899-911. PMID: 15197101
- FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils. | Sharma, SS., et al. 2007. Pharmacol Res. 55: 335-42. PMID: 17292620
- A peroxynitrite decomposition catalyst: FeTPPS confers cardioprotection during reperfusion after cardioplegic arrest in a working isolated rat heart model. | Lauzier, B., et al. 2007. Fundam Clin Pharmacol. 21: 173-80. PMID: 17391290
- The metalloporphyrin FeTPPS but not by cyclosporin A antagonizes the interaction of peroxynitrate and hydrogen peroxide on cardiomyocyte cell death. | Klassen, SS. and Rabkin, SW. 2009. Naunyn Schmiedebergs Arch Pharmacol. 379: 149-61. PMID: 18773197
- The acute and chronic phases of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE) are ameliorated by the peroxynitrite decomposition catalyst, 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinatoiron (III) chloride, (FeTPPS). | Bolton, C., et al. 2008. Eur J Pharmacol. 601: 88-93. PMID: 18977216
- Neurovascular protective effect of FeTPPs in N-methyl-D-aspartate model: similarities to diabetes. | Al-Gayyar, MM., et al. 2010. Am J Pathol. 177: 1187-97. PMID: 20651233
- Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn rats. | Belik, J., et al. 2010. Free Radic Biol Med. 49: 1306-14. PMID: 20688155
- FeTPPS Reduces Secondary Damage and Improves Neurobehavioral Functions after Traumatic Brain Injury. | Bruschetta, G., et al. 2017. Front Neurosci. 11: 6. PMID: 28223911
- 5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride (FeTPPS), a peroxynitrite decomposition catalyst, catalyzes protein tyrosine nitration in the presence of hydrogen peroxide and nitrite. | Zhang, P., et al. 2018. J Inorg Biochem. 183: 9-17. PMID: 29525695
- Study on the detoxification mechanisms to 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron(III) chloride (FeTPPS), an efficient pro-oxidant of heme water-soluble analogue. | Zhang, P., et al. 2018. J Inorg Biochem. 189: 40-52. PMID: 30218889
- Peroxynitrite scavenger FeTPPS effectively inhibits hIAPP aggregation and protects against amyloid induced cytotoxicity. | Zhang, P., et al. 2020. Int J Biol Macromol. 161: 336-344. PMID: 32522548
- Entacapone scavenges peroxynitrite and protects against kidney and liver injuries induced by renal ischemia/reperfusion in rats. | Soliman, E., et al. 2021. Int Urol Nephrol. 53: 1713-1721. PMID: 33675481
- A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. | Wang, X., et al. 2021. Cell Death Dis. 12: 402. PMID: 33854044
- Stimulation of Akt Phosphorylation and Glucose Transport by Metalloporphyrins with Peroxynitrite Decomposition Catalytic Activity. | Eccardt, AM., et al. 2022. Catalysts. 12: PMID: 37123089
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FeTPPS, 250 mg | sc-221611 | 250 mg | $215.00 | |||
FeTPPS, 1 g | sc-221611A | 1 g | $620.00 |