Molecular structure of Ferrostatin 1, CAS Number: 347174-05-4
Ferrostatin 1 (CAS 347174-05-4)
See product citations (15)
Alternate Names:
3-Amino-4-cyclohexylaminobenzoic Acid Ethyl Ester; Fer-1
Application:
Ferrostatin 1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis
CAS Number:
347174-05-4
Molecular Weight:
262.35
Molecular Formula:
C15H22N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ferrostatin 1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin 1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin 1 controls lipid soluble ROS.
Ferrostatin 1 (CAS 347174-05-4) References
- The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells. | Kabiraj, P., et al. 2015. Protein J. 34: 349-58. PMID: 26385697
- MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells. | Ito, K., et al. 2017. Cell Death Discov. 3: 17013. PMID: 28250973
- On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. | Zilka, O., et al. 2017. ACS Cent Sci. 3: 232-243. PMID: 28386601
- Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. | Horwath, MC., et al. 2017. Chembiochem. 18: 2069-2078. PMID: 28783875
- Insight into the mechanism of ferroptosis inhibition by ferrostatin-1. | Miotto, G., et al. 2020. Redox Biol. 28: 101328. PMID: 31574461
- Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. | Liu, P., et al. 2020. Cell Mol Biol Lett. 25: 10. PMID: 32161620
- Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1. | Dong, H., et al. 2020. Aging (Albany NY). 12: 12943-12959. PMID: 32601262
- Ferrostatin-1 alleviates angiotensin II (Ang II)- induced inflammation and ferroptosis in astrocytes. | Li, S., et al. 2021. Int Immunopharmacol. 90: 107179. PMID: 33278745
- Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice. | Feng, X., et al. 2021. Front Endocrinol (Lausanne). 12: 626390. PMID: 33679620
- Ferrostatin-1 alleviated TNBS induced colitis via the inhibition of ferroptosis. | Xu, J., et al. 2021. Biochem Biophys Res Commun. 573: 48-54. PMID: 34388454
- Ferrostatin-1 Alleviates White Matter Injury Via Decreasing Ferroptosis Following Spinal Cord Injury. | Ge, H., et al. 2022. Mol Neurobiol. 59: 161-176. PMID: 34635980
- Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction. | Xiao, Z., et al. 2021. Bioengineered. 12: 9367-9376. PMID: 34787054
- Ferrostatin-1 modulates dysregulated kidney lipids in acute kidney injury. | Martín-Saiz, L., et al. 2022. J Pathol. 257: 285-299. PMID: 35152438
- Ferrostatin-1 and 3-Methyladenine Ameliorate Ferroptosis in OVA-Induced Asthma Model and in IL-13-Challenged BEAS-2B Cells. | Yang, N. and Shang, Y. 2022. Oxid Med Cell Longev. 2022: 9657933. PMID: 35154576
- Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis. | Xie, J., et al. 2022. Mol Med Rep. 26: PMID: 35703358
Inhibitor of:
Apoptosis, BOLA2B, Cytochrome c, EG434729, ENDOG, and TMEM164.Activator of:
ABCB7, ERIS, and STAMP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ferrostatin 1, 10 mg | sc-498126 | 10 mg | $165.00 | |||
Ferrostatin 1, 50 mg | sc-498126A | 50 mg | $451.00 |