ferritin Antibody (5E596): sc-71102
- ferritin Antibody (5E596) is a mouse monoclonal IgG3 ferritin antibody provided at 100 µg/ml
- raised against purified human ferritin
- recommended for detection of ferritin of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ferritin Antibody (5E596). This work is in progress.
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ferritin Antibody (5E596) is a mouse monoclonal IgG3 antibody that detects ferritin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ferritin antibody (5E596) is available as the non-conjugated format. Ferritin plays a crucial role in iron metabolism, serving as the primary intracellular iron storage protein, which is essential for maintaining iron homeostasis in cells. Ferritin is composed of 24 subunits that form a hollow spherical structure, allowing ferritin to sequester iron in a soluble and non-toxic form. This structure enables ferritin to store large amounts of iron, releasing iron in a controlled manner to meet cellular needs, thereby preventing iron overload, which can lead to oxidative stress and cellular damage. Additionally, ferritin heavy chain is involved in the regulation of thymidine biosynthesis, which is critical for DNA synthesis and cell proliferation, particularly in cancer cells like MCF-7. The gene encoding human ferritin heavy chain is located on chromosome 11q13, while the light chain gene is found on chromosome 19q13.3-q13.4, highlighting the genetic basis for ferritin′s function and importance in various physiological and pathological processes.
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ferritin Antibody (5E596) References:
- High level of ferritin light chain mRNA in lens. | Cheng, Q., et al. 2000. Biochem Biophys Res Commun. 270: 349-55. PMID: 10753629
- Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis. | Oppenheim, EW., et al. 2001. J Biol Chem. 276: 19855-61. PMID: 11278996
- Sulfide is an efficient iron releasing agent for mammalian ferritins. | Cassanelli, S. and Moulis, J. 2001. Biochim Biophys Acta. 1547: 174-82. PMID: 11343803
- Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter. | Worwood, M., et al. 1985. Hum Genet. 69: 371-4. PMID: 3857215
- Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution. | Hempstead, PD., et al. 1997. J Mol Biol. 268: 424-48. PMID: 9159481
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ferritin Antibody (5E596) | sc-71102 | 100 µg/ml | $322.00 |