Molecular structure of Feprazone, CAS Number: 30748-29-9
Feprazone (CAS 30748-29-9)
Application:
Feprazone is inducer of the P-450 2B family of cytochromes
CAS Number:
30748-29-9
Molecular Weight:
320.38
Molecular Formula:
C20H20N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Feprazone is a non-steroidal, anti-inflammatory compound. Feprazone is noted to be structurally similar to phenylbutazone (sc-204843; deuterium-labelled sc-219696) and has been utilized in research studies analyzing the induction of P-450 where Feprazon was reported to induce the P450 II B family of cytochromes. Metabolization of Feprazone by CYP2B is reported to occur at two positons on the side chains of the compound through a molecular modeling of the interaction of the Feprazon and mammalian CYP2B.
Feprazone (CAS 30748-29-9) References
- Feprazone: an inducer of the P450 II B family of proteins in the rat. | Smith, JN., et al. 1990. J Biochem Toxicol. 5: 9-12. PMID: 2402005
- Feprazone Prevents Free Fatty Acid (FFA)-Induced Endothelial Inflammation by Mitigating the Activation of the TLR4/MyD88/NF-κB Pathway. | Song, M., et al. 2021. ACS Omega. 6: 4850-4856. PMID: 33644593
- Feprazone Displays Antiadipogenesis and Antiobesity Capacities in in Vitro 3 T3-L1 Cells and in Vivo Mice. | Che, L., et al. 2021. ACS Omega. 6: 6674-6680. PMID: 33748580
- Feprazone Ameliorates TNF-α-Induced Loss of Aggrecan via Inhibition of the SOX-4/ADAMTS-5 Signaling Pathway. | Xiong, X., et al. 2021. ACS Omega. 6: 7638-7645. PMID: 33778274
- Feprazone Mitigates IL-1β-Induced Cellular Senescence in Chondrocytes. | Huang, Z., et al. 2021. ACS Omega. 6: 9442-9448. PMID: 33869924
- Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway. | Ye, J., et al. 2022. Mar Drugs. 20: PMID: 35447899
- Comparison of the effects of feprazone and phenylbutazone on testosterone hydroxylations in mouse hepatic microsomes. | Morita, K., et al. 1986. Chem Pharm Bull (Tokyo). 34: 214-20. PMID: 3698130
- Specimen handling in an HPLC determination of phenylbutazone and its major metabolites in plasma, avoiding degradation of the compounds. | Franssen, MJ., et al. 1986. Pharm Weekbl Sci. 8: 229-33. PMID: 3763367
- High-pressure liquid chromatographic feprazone determination in pharmaceutical formulations. | Bonora, A. and Borea, PA. 1979. J Pharm Sci. 68: 798-800. PMID: 458589
- Molecular modelling of mammalian CYP2B isoforms and their interaction with substrates, inhibitors and redox partners. | Lewis, DF. and Lake, BG. 1997. Xenobiotica. 27: 443-78. PMID: 9179987
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Feprazone, 200 mg | sc-279162 | 200 mg | $200.00 |