Molecular structure of Fenoldopam hydrochloride, CAS Number: 67227-56-9
Fenoldopam hydrochloride (CAS 67227-56-9)
Alternate Names:
6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrochloride
Application:
Fenoldopam hydrochloride is a selective D1-like dopamine receptor partial agonist
CAS Number:
67227-56-9
Molecular Weight:
342.22
Molecular Formula:
C16H16ClNO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fenoldopam hydrochloride is a potent and selective dopamine receptor agonist that functions by activating dopamine receptors in smooth muscle cells, leading to vasodilation. This chemical′s mechanism of action involves stimulating dopamine receptors, particularly the D1 subtype, which results in relaxation of vascular smooth muscle and subsequent dilation of peripheral blood vessels. By specifically targeting dopamine receptors, fenoldopam hydrochloride exerts its vasodilatory effects without affecting other receptors, making it useful for studying the role of dopamine in vascular function. At the molecular level, fenoldopam hydrochloride binds to and activates dopamine receptors, triggering a cascade of intracellular signaling events that ultimately lead to vasodilation.
Fenoldopam hydrochloride (CAS 67227-56-9) References
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- Gbeta regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development. | Li, XX., et al. 2000. Am J Physiol Regul Integr Comp Physiol. 278: R931-6. PMID: 10749781
- Histopathological and immunohistochemical studies on arteritis induced by fenoldopam, a vasodilator, in rats. | Ikegami, H., et al. 2001. Exp Toxicol Pathol. 53: 25-30. PMID: 11370730
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- Renoprotective role of fenoldopam pretreatment through hypoxia-inducible factor-1alpha and heme oxygenase-1 expressions in rat kidney transplantation. | Yi, X., et al. 2013. Transplant Proc. 45: 517-22. PMID: 23498787
- The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. | Gildea, JJ., et al. 2014. Kidney Int. 86: 118-26. PMID: 24552847
- Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles. | Pala, R., et al. 2019. ACS Nano. 13: 3555-3572. PMID: 30860808
- Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. | Zheng, Y., et al. 2021. Bioorg Chem. 108: 104561. PMID: 33349457
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- Effects of dopexamine on heart function of isolated hypoxic rabbit heart and in comparison with fenoldopam and procaterol. | Qin, FZ., et al. 1996. Zhongguo Yao Li Xue Bao. 17: 435-8. PMID: 9863168
Inhibitor of:
AR, C11orf20, and DARPP-32.Activator of:
β-sarcoglycan, D1DR, and GRK 5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fenoldopam hydrochloride, 10 mg | sc-279160 | 10 mg | $159.00 |