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Fenofibrate (CAS 49562-28-9)

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Alternate Names:
Procetofen; Trilipix
Application:
Fenofibrate is a hypolipidemic PPARα agonist
CAS Number:
49562-28-9
Purity:
≥98%
Molecular Weight:
360.83
Molecular Formula:
C20H21ClO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fenofibrate is a hypolipidemic compound which acts as a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist (EC50 = 18 muM for mouse and EC50 = 30 muM for human). Fenofibrate also binds to PPARgamma with at least 10-fold less affinity, and is inactive at PPARdelta at concentrations up to 100 muM.


Fenofibrate (CAS 49562-28-9) References

  1. Fenofibrate improves vascular endothelial function in diabetic mice.  |  Xin, R., et al. 2019. Biomed Pharmacother. 112: 108722. PMID: 30970521
  2. Fenofibrate increases the amount of sulfatide which seems beneficial against Covid-19.  |  Buschard, K. 2020. Med Hypotheses. 143: 110127. PMID: 32759008
  3. Fenofibrate treatment for severe hypertriglyceridemia in dogs.  |  Miceli, DD., et al. 2021. Domest Anim Endocrinol. 74: 106578. PMID: 33137654
  4. Fenofibrate Regulates Visceral Obesity and Nonalcoholic Steatohepatitis in Obese Female Ovariectomized C57BL/6J Mice.  |  Shin, Y., et al. 2021. Int J Mol Sci. 22: PMID: 33916086
  5. Fenofibrate improves GLOBE and UK-PBC scores and histological features in primary biliary cholangitis.  |  Wang, L., et al. 2022. Minerva Med. 113: 974-982. PMID: 33949176
  6. Fenofibrate diminishes the self-renewal and metastasis potentials of oral carcinoma stem cells through NF-κB signaling.  |  Su, TR., et al. 2022. J Formos Med Assoc. 121: 1900-1907. PMID: 35151562
  7. Fenofibrate Increases the Population of Non-Classical Monocytes in Asymptomatic Chagas Disease Patients and Modulates Inflammatory Cytokines in PBMC.  |  Pieralisi, AV., et al. 2021. Front Cell Infect Microbiol. 11: 785166. PMID: 35360222
  8. Association of Fenofibrate Use and the Risk of Progression to Vision-Threatening Diabetic Retinopathy.  |  Meer, E., et al. 2022. JAMA Ophthalmol. 140: 529-532. PMID: 35389455
  9. Fenofibrate Exerts Anticancer Effects on Human Cervical Cancer HeLa Cells via Caspase-Dependent Apoptosis and Cell Cycle Arrest.  |  Song, SY., et al. 2022. Gynecol Obstet Invest. 87: 79-88. PMID: 35500567
  10. PPAR-α Agonist Fenofibrate Ameliorates Sjögren Syndrome-Like Dacryoadenitis by Modulating Th1/Th17 and Treg Cell Responses in NOD Mice.  |  Guo, X., et al. 2022. Invest Ophthalmol Vis Sci. 63: 12. PMID: 35687344
  11. Fenofibrate Ameliorated Systemic and Retinal Inflammation and Modulated Gut Microbiota in High-Fat Diet-Induced Mice.  |  Wang, X., et al. 2022. Front Cell Infect Microbiol. 12: 839592. PMID: 35719341
  12. Fenofibrate mediated activation of PPARα negatively regulates trophoblast invasion.  |  Singh, S., et al. 2022. Placenta. 126: 140-149. PMID: 35803128
  13. Fenofibrate Attenuates Radiation-Induced Oxidative Damage to the Skin through Fatty Acid Binding Protein 4 (FABP4).  |  Sun, C., et al. 2022. Front Biosci (Landmark Ed). 27: 214. PMID: 35866401
  14. Fenofibrate ameliorates letrozole-induced polycystic ovary in rats via modulation of PPARα and TNFα/CD95 pathway.  |  Morsy, MA., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 7359-7370. PMID: 36314306

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fenofibrate, 5 g

sc-204751
5 g
$40.00

Dear, could you please send me a price quote for 10kg of fenofibrate? Could you also send me some information about the API (morphology, PSD) as this material will be used in a PhD project? Best regards, Maxim.

Asked by: Maxim Pauwels
Thank you for your question. Please contact our Special Orders Department to inquire about the possibility of a bulk order for this biochemical. Email us at specialorders@scbt.com.
Answered by: Tech Service
Date published: 2018-08-03
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Rated 5 out of 5 by from WuWu, Y. et al. (PubMed 26387199) used Fenofibrate, a PPAR agonist, to demonstrate that PPAR- can negatively regulate cardiomyocyte hypertrophy. -SCBT Publication Review
Date published: 2015-03-14
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Fenofibrate is rated 5.0 out of 5 by 1.
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