Date published: 2026-5-1

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Fenbufen (CAS 36330-85-5)

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Application:
Fenbufen is an anti-inflammatory analgesic
CAS Number:
36330-85-5
Purity:
≥98%
Molecular Weight:
254.28
Molecular Formula:
C16H14O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fenbufen is a nonsteroidal anti-inflammatory compound that functions as an inhibitor of cyclooxygenase, specifically COX-1 and COX-2 enzymes. It exerts its mechanism of action by blocking the conversion of arachidonic acid to prostaglandin H2, thereby reducing the production of prostaglandins, which are mediators of inflammation, pain, and fever. By inhibiting the activity of COX enzymes, fenbufen interferes with the synthesis of prostaglandins, ultimately leading to a decrease in inflammatory responses and pain sensation. Fenbufen′s mechanism of action involves reversible binding to the active site of COX enzymes, preventing the conversion of arachidonic acid to prostaglandins. In a research and development setting, fenbufen′s role lies in its ability to modulate inflammatory and pain pathways at the molecular level, providing insights into the biological processes underlying inflammation and pain.


Fenbufen (CAS 36330-85-5) References

  1. Effect of fenbufen on the entry of new quinolones, norfloxacin and ofloxacin, into the central nervous system in rats.  |  Ichikawa, N., et al. 1992. J Pharm Pharmacol. 44: 915-20. PMID: 1361537
  2. Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.  |  Husain, A., et al. 2009. Eur J Med Chem. 44: 3798-804. PMID: 19457595
  3. Single dose oral fenbufen for acute postoperative pain in adults.  |  Moore, RA., et al. 2009. Cochrane Database Syst Rev. 2009: CD007547. PMID: 19821427
  4. Synthesis and structure-activity relationships of fenbufen amide analogs.  |  Lin, KI., et al. 2010. Molecules. 15: 8796-803. PMID: 21127465
  5. Inhibition of ATP synthesis by fenbufen and its conjugated metabolites in rat liver mitochondria.  |  Syed, M., et al. 2016. Toxicol In Vitro. 31: 23-9. PMID: 26612354
  6. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs.  |  Child, RG., et al. 1977. J Pharm Sci. 66: 466-76. PMID: 300797
  7. Fenbufen compared with indomethacin in osteoarthrosis.  |  Buxton, R., et al. 1978. Curr Med Res Opin. 5: 682-7. PMID: 367713
  8. Fenbufen Alleviates Severe Acute Pancreatitis by Suppressing Caspase-1/Caspase-11-mediated Pyroptosis in Mice.  |  Shen, S., et al. 2023. Curr Mol Pharmacol.. PMID: 37165681
  9. A review of the effects of fenbufen and a metabolite, biphenylacetic acid, on platelet biochemistry and function.  |  Kohler, C., et al. 1980. Arzneimittelforschung. 30: 702-7. PMID: 6254545
  10. Pharmacologic properties of fenbufen.  |  Kerwar, SS. 1983. Am J Med. 75: 62-9. PMID: 6356910
  11. Fenbufen, a new non-steroidal anti-inflammatory agent in rheumatoid arthritis, its efficacy and toxicity.  |  Becker, A. and Hoffmeister, RT. 1980. J Int Med Res. 8: 333-8. PMID: 6998793
  12. The pharmacological properties of fenbufen. A review.  |  Sloboda, AE., et al. 1980. Arzneimittelforschung. 30: 716-21. PMID: 7002162
  13. Fenbufen: a review of its pharmacological properties and therapeutic use in rheumatic diseases and acute pain.  |  Brogden, RN., et al. 1981. Drugs. 21: 1-22. PMID: 7009135
  14. Pharmacological properties of fenbufen.  |  Kerwar, SS. and Sloboda, AE. 1982. Pharmacology. 25 Suppl 1: 12-20. PMID: 7111379

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fenbufen, 1 g

sc-204750
1 g
$47.00

Fenbufen, 5 g

sc-204750A
5 g
$79.00