Molecular structure of Felodipine, CAS Number: 72509-76-3
Felodipine (CAS 72509-76-3)
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Alternate Names:
Plendil
Application:
Felodipine is a 1,4-dihydropyridine antagonist and calcium channel protein inhibitor
CAS Number:
72509-76-3
Molecular Weight:
384.3
Molecular Formula:
C18H19Cl2NO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Felodipine is a 1,4-dihydropyridine small molecule antagonist and calcium channel protein inhibitor. Antagonism of the vascular L-type (long-lasting) calcium channel decreases intracellular calcium concentration, softening the tone of vascular tissue and decreasing the peripheral resistance upon the blood stream, effectively decreasing systemic arterial blood pressure without affecting myocardial contractility. Felodipine is described to inhibit cytokine-induced NO and superoxide production as well as cytokine-induced NO synthase (NOS) mRNA induction, and is suggested to act as a scavenger of superoxide and not an inhibitor of inducible NOS induction. This indicates that Felodipine further protects the vasculature against endogenous free radical generation during inflammatory responses.
Felodipine (CAS 72509-76-3) References
- Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues. | Angus, JA., et al. 2000. Clin Exp Pharmacol Physiol. 27: 1019-21. PMID: 11117223
- Felodipine pharmacokinetics and plasma concentration vs effect relationships. | Blychert, E. 1992. Blood Press Suppl. 2: 1-30. PMID: 1343111
- Vascular selectivity of felodipine: experimental pharmacology. | Ljung, B. 1990. J Cardiovasc Pharmacol. 15 Suppl 4: S11-6. PMID: 1693715
- Felodipine: a new dihydropyridine calcium-channel antagonist. | Yedinak, KC. and Lopez, LM. 1991. DICP. 25: 1193-206. PMID: 1763537
- Augmented bioavailability of felodipine through an α-linolenic acid-based microemulsion. | Singh, M., et al. 2018. Drug Deliv Transl Res. 8: 204-225. PMID: 29204927
- Appraisal of Felodipine Nanocrystals for Solubility Enhancement and Pharmacodynamic Parameters on Cadmium Chloride Induced Hypertension in Rats. | Maurya, P., et al. 2022. Curr Drug Deliv. 19: 625-634. PMID: 34325637
- The Physical Stability of Felodipine and Its Recrystallization from an Amorphous Solid Dispersion Studied by NMR Relaxometry. | Pajzderska, A., et al. 2022. AAPS PharmSciTech. 23: 93. PMID: 35314906
- Vascular versus myocardial effects of calcium antagonists. | Little, WC. and Cheng, CP. 1994. Drugs. 47 Suppl 4: 41-5; discussion 45-6. PMID: 7523061
- The evolving role of calcium channel blockers in the treatment of angina pectoris: focus on felodipine. | Gradman, AH. 1995. Can J Cardiol. 11 Suppl B: 14B-21B. PMID: 7728649
- Vascular selective calcium entry blockers in the treatment of cardiovascular disorders: focus on felodipine. | Little, WC., et al. 1995. Cardiovasc Drugs Ther. 9: 657-63. PMID: 8573548
- High blood pressure and calcium antagonism. | Palma-Gámiz, JL. 1997. Cardiology. 88 Suppl 1: 39-46. PMID: 9118167
- Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists. | Sarsero, D., et al. 1998. Br J Pharmacol. 125: 109-19. PMID: 9776350
- Felodipine inhibits free-radical production by cytokines and glucose in human smooth muscle cells. | Hishikawa, K. and Lüscher, TF. 1998. Hypertension. 32: 1011-5. PMID: 9856965
Inhibitor of:
CA II, CA XI, CaBP2, Cacna2d1, Cacna2d2, Cacna2d3, Cacna2d4, Calcium Channel Protein, calsequestrin 2, CaMKIIβ, CAMTA1, CAPS-2, CLCA2_Clac2, L-type Ca++ CP α1C, L-type Ca++ CP α1C/1D/1F/1S, L-type Ca++ CP α1S, L-type Ca++ CP β1, L-type Ca++ CP β2, L-type Ca++ CP β4, L-type Ca++ CP γ1, L-type Ca++ CP γ2, L-type Ca++ CP γ4, L-type Ca++ CP γ6, L-type Ca++ CP γ7, L-type Ca++ CP γ8, L-type calcium channel α1C, L-type calcium channel α1D, L-type calcium channel α1F, L-type calcium channel β1, L-type Calcium Channel γ, NCKX5, Olfr769, Olfr960, Olr1479, Olr1595, Olr24, Olr409, Olr434, Olr853, Raftlin, S-100Z, SCRN1, TMEM184B, TRAP-δ, Troponin C slow skeletal, Troponin T, and VPS51.Activator of:
5330417C22Rik, KV4.1, L-type Ca++ CP α1F, L-type Ca++ CP γ4, L-type Ca++ CP γ5, L-type Ca++ CP γ7, L-type calcium channel α1C, LHFPL2, Limkain b1, NCKX1, NCKX6, T-type Ca++ CP α1I, and Triadin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Felodipine, 10 mg | sc-201483 | 10 mg | $89.00 | |||
Felodipine, 50 mg | sc-201483A | 50 mg | $218.00 |