FDPS Antibody (104J2E): sc-517603

FDPS Antibody (104J2E) is a mouse monoclonal IgG2b kappa light chain antibody that detects FDPS protein of mouse, rat, and human origin by western blotting (WB). Anti-FDPS antibody (104J2E) is available as the non-conjugated format. FDPS, also known as farnesyl diphosphate synthase, is a crucial enzyme consisting of 419 amino acids and belongs to the FPP/GGPP synthetase family. FDPS is primarily localized in the cytoplasm and peroxisomes, where FDPS plays a vital role in cholesterol biosynthesis, post-translational protein modifications, and synthesis of steroid hormones within the isoprenoid pathway. FDPS catalyzes the formation of farnesyl diphosphate (FPP), which serves as a precursor for several essential metabolites, including sterols, dolichols, carotenoids, and ubiquinones. Regulation of FDPS expression by phorbol esters and polyunsaturated fatty acids highlights FDPS importance in cellular signaling and metabolic processes. FDPS exists as a homodimer and may exhibit anti-viral effects when inactivated by interferon-induced RSAD2, which can disrupt lipid rafts at the plasma membrane. Reduced activity of FDPS in the liver has been implicated in the pathogenesis of Zellweger syndrome and neonatal adrenoleukodystrophy, both peroxisomal deficiency diseases.

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FDPS Antibody (104J2E) References:

1. The isoprenoid pathway in the ectomycorrhizal fungus Tuber borchii Vittad.: cloning and characterisation of the tbhmgr, tbfpps and tbsqs genes.  |  Guidi, C., et al. 2006. Curr Genet. 50: 393-404. PMID: 16960710
2. Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones.  |  Cusson, M., et al. 2006. Proteins. 65: 742-58. PMID: 16972283
3. Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.  |  Mao, J., et al. 2006. J Am Chem Soc. 128: 14485-97. PMID: 17090032
4. Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin.  |  Leon, A., et al. 2006. J Med Chem. 49: 7331-41. PMID: 17149863
5. Farnesyl diphosphate synthase: a novel genotype association with bone mineral density in elderly women.  |  Levy, ME., et al. 2007. Maturitas. 57: 247-52. PMID: 17368768
6. Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells.  |  Ory, B., et al. 2008. J Cell Mol Med. 12: 928-41. PMID: 18494934
7. Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis.  |  Marini, F., et al. 2008. Curr Med Res Opin. 24: 2609-15. PMID: 18687167
8. Characterization and functional analysis of cis-acting elements of the human farnesyl diphosphate synthetase (FDPS) gene 5' flanking region.  |  Romanelli, MG., et al. 2009. Genomics. 93: 227-34. PMID: 19056481
9. Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells.  |  Li, J., et al. 2009. J Immunol. 182: 8118-24. PMID: 19494338