Date published: 2025-12-5

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FC 131 (CAS 606968-52-9)

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Alternate Names:
Cyclo[2-Nal-Gly-D-Tyr-Arg-Arg]
Application:
FC 131 is an antagonist of CXCR4 with anti-HIV activity
CAS Number:
606968-52-9
Molecular Weight:
729.84
Molecular Formula:
C36H47N11O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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FC 131, a chemical compound of interest in scientific research, has garnered attention due to its potential mechanisms of action and diverse research applications. While specific details regarding its mechanism of action may vary based on ongoing studies, FC 131 is believed to exert its effects through modulation of intracellular signaling pathways or interaction with molecular targets involved in cellular processes. In research settings, FC 131 has been utilized to investigate various biological phenomena, ranging from cellular signaling cascades to molecular interactions within cellular compartments. Its applications span across multiple disciplines, including cell biology, biochemistry, pharmacology, and neuroscience. Researchers have employed FC 131 to explain the roles of specific signaling molecules, study cellular responses to external stimuli, and explore potential targets for various diseases. Furthermore, FC 131′s chemical properties and structural characteristics make it a valuable tool for designing novel experiments aimed at uncovering the complexities of cellular function and unraveling the molecular mechanisms underlying physiological and pathological processes. As research in this area continues to evolve, FC 131 remains a promising compound for advancing our understanding of fundamental biological processes and informing the development of future research strategies.


FC 131 (CAS 606968-52-9) References

  1. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.  |  Tamamura, H., et al. 2005. J Med Chem. 48: 380-91. PMID: 15658852
  2. Development of anti-HIV agents targeting dynamic supramolecular mechanism: entry and fusion inhibitors based on CXCR4/CCR5 antagonists and gp41-C34-remodeling peptides.  |  Tamamura, H., et al. 2005. Curr HIV Res. 3: 289-301. PMID: 16250877
  3. Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis.  |  Tamamura, H., et al. 2007. Curr Med Chem. 14: 93-102. PMID: 17266570
  4. Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres.  |  Narumi, T., et al. 2010. Org Biomol Chem. 8: 616-21. PMID: 20090978
  5. Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists.  |  Mandawat, A., et al. 2010. Blood. 116: 5306-15. PMID: 20810927
  6. Structure-activity relationship study of a CXC chemokine receptor type 4 antagonist, FC131, using a series of alkene dipeptide isosteres.  |  Kobayashi, K., et al. 2012. J Med Chem. 55: 2746-57. PMID: 22352868
  7. Imaging agents for the chemokine receptor 4 (CXCR4).  |  Kuil, J., et al. 2012. Chem Soc Rev. 41: 5239-61. PMID: 22743644
  8. Analysis by substituted cysteine scanning mutagenesis of the fourth transmembrane domain of the CXCR4 receptor in its inactive and active state.  |  Boulais, PE., et al. 2013. Biochem Pharmacol. 85: 541-50. PMID: 23219524
  9. Potent CXCR4 antagonists containing amidine type Peptide bond isosteres.  |  Inokuchi, E., et al. 2011. ACS Med Chem Lett. 2: 477-80. PMID: 24900333
  10. Development of novel CXC chemokine receptor 7 (CXCR7) ligands: selectivity switch from CXCR4 antagonists with a cyclic pentapeptide scaffold.  |  Oishi, S., et al. 2015. J Med Chem. 58: 5218-25. PMID: 26042340

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

FC 131, 1 mg

sc-362738
1 mg
$430.00
US: Only available in the US