FBXO7 Antibody (E-8): sc-271763

FBXO7 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects FBXO7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FBXO7 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FBXO7, also known as F-box protein 7, is a crucial component of the SCF (Skp1-CUL-1-F-box protein) E3 ubiquitin ligase complex, which plays a vital role in substrate recognition and recruitment for ubiquitination. FBXO7 is involved in the regulation of numerous cellular processes, including cell cycle, immune responses, signaling pathways, and developmental events, by targeting specific proteins such as cyclins and cyclin-dependent kinase inhibitors for proteasomal degradation. FBXO7 contains one F-box domain and is composed of 522 amino acids, which is essential for its function within the SCF complex. Defects in the gene encoding FBXO7 have been linked to parkinsonian-pyramidal syndrome (PKPS), a disorder characterized by hypokinetic rigidity and symptoms associated with both Parkinson′s disease and pyramidal tract dysfunction, highlighting FBXO7′s significance in maintaining neurological health.

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FBXO7 Antibody (E-8) References:

1. Identification of a family of human F-box proteins.  |  Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
2. A family of mammalian F-box proteins.  |  Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
3. cDNA cloning and expression analysis of new members of the mammalian F-box protein family.  |  Ilyin, GP., et al. 2000. Genomics. 67: 40-7. PMID: 10945468
4. Systematic analysis and nomenclature of mammalian F-box proteins.  |  Jin, J., et al. 2004. Genes Dev. 18: 2573-80. PMID: 15520277
5. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination.  |  Chang, YF., et al. 2006. Biochem Biophys Res Commun. 342: 1022-6. PMID: 16510124
6. Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor.  |  Kirk, R., et al. 2008. J Biol Chem. 283: 22325-35. PMID: 18495667
7. Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays.  |  Shojaee, S., et al. 2008. Am J Hum Genet. 82: 1375-84. PMID: 18513678
8. FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome.  |  Di Fonzo, A., et al. 2009. Neurology. 72: 240-5. PMID: 19038853
9. A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells.  |  Shen, JZ., et al. 2022. Mol Cell. 82: 1123-1139.e8. PMID: 35182481
10. The characteristics of FBXO7 and its role in human diseases.  |  Zhong, Y., et al. 2023. Gene. 851: 146972. PMID: 36261086
11. FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.  |  Li, S., et al. 2023. Adv Sci (Weinh). 10: e2303561. PMID: 37822160
12. FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma.  |  Luo, L., et al. 2024. Nat Commun. 15: 4790. PMID: 38839752

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FBXO7 Antibody (E-8) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-FBXO7 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FBXO7 Antibody (E-8) Specifications

Alternate Product Name: FBXO7

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 427-461

Epitope Target: FBXO7

Epitope Species: human

Product Reactivity/Detection: FBXO7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for FBXO7 Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin