Molecular structure of FBPase-1 Inhibitor, CAS Number: 883973-99-7
FBPase-1 Inhibitor (CAS 883973-99-7)
See product citations (4)
Alternate Names:
5-Chloro-2-(N-(2,5-dichlorobenzenesulfonamido))-benzoxazole
Application:
FBPase-1 Inhibitor is a cell-permeable benzoxazolo-sulfonamide compound
CAS Number:
883973-99-7
Purity:
≥97%
Molecular Weight:
377.6
Molecular Formula:
C13H7Cl3N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FBPase-1 Inhibitor is a cell-permeable benzoxazolo-sulfonamide compound that inhibits hFBPase-1 enzymatic activity by competing at the AMP allosteric binding site. FBPase-1 Inhibitor has been shown to block glucose production in starved rat hepatoma cells.
FBPase-1 Inhibitor (CAS 883973-99-7) References
- Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. | von Geldern, TW., et al. 2006. Bioorg Med Chem Lett. 16: 1811-5. PMID: 16442285
- Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. | Lai, C., et al. 2006. Bioorg Med Chem Lett. 16: 1807-10. PMID: 16446092
- Tissue Specific Effects of Dietary Carbohydrates and Obesity on ChREBPα and ChREBPβ Expression. | Stamatikos, AD., et al. 2016. Lipids. 51: 95-104. PMID: 26526060
- Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage. | Lai, L., et al. 2019. Circulation. 139: 119-133. PMID: 30586707
- Potential therapies targeting nuclear metabolic regulation in cancer. | Chen, Y., et al. 2023. MedComm (2020). 4: e421. PMID: 38034101
- Carbohydrate metabolism a: glycolysis and gluconeogenesis[J]. | Fromm H J, Hargrove M, Fromm H J,., 2012: Essentials of Biochemistry. 16.
- Recent advances in the development of pharmacologically active compounds that contain a benzoxazole scaffold[J]. | Singh S, Veeraswamy G, Bhattarai D,. 2015,. Asian Journal of Organic Chemistry,. 4(12):: 1338-1361.
Inhibitor of:
Enzyme, and liver FBPase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FBPase-1 Inhibitor, 10 mg | sc-221608 | 10 mg | $168.00 |