FBPase-1 Inhibitor CAS: 883973-99-7
MF: C13H7Cl3N2O3S
MW: 377.6
A cell-permeable benzoxazolo-sulfonamide compound.

FBPase-1 Inhibitor (CAS 883973-99-7)

FBPase-1 Inhibitor | CAS 883973-99-7 is rated 5.0 out of 5 by 1.
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Alternate Names: 5-Chloro-2-(N-(2,5-dichlorobenzenesulfonamido))-benzoxazole
Application: FBPase-1 Inhibitor is a cell-permeable benzoxazolo-sulfonamide compound
CAS Number: 883973-99-7
Purity: ≥97%
Molecular Weight: 377.6
Molecular Formula: C13H7Cl3N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

FBPase-1 Inhibitor is a cell-permeable benzoxazolo-sulfonamide compound that inhibits hFBPase-1 enzymatic activity by competing at the AMP allosteric binding site. FBPase-1 Inhibitor has been shown to block glucose production in starved rat hepatoma cells.


References

1. von Geldern, Thomas W., et al., 2006. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. Bioorganic & medicinal chemistry letters. 16(7): 1811-5. PMID: 16442285
2. Lai, Chunqiu., et al., 2006. Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorganic & medicinal chemistry letters. 16(7): 1807-10. PMID: 16446092

Physical State :
Solid
Solubility :
Soluble in DMSO
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6102820
SMILES :
C1=CC2=C(C=C1Cl)N=C(O2)NS(=O)(=O)C3=C(C=CC(=C3)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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FBPase-1 Inhibitor (CAS 883973-99-7)  Product Citations

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PMID: # 23718875  2013. Nutr Metab (Lond). 10: 40.

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What is the half-life of sc-221608?

Asked by: ChemSynth123
Thank you for your question. FBPase-1 Inhibitor (CAS 883973-99-7): sc-221608 is stable for at least a year if stored at 4ºC.
Answered by: Chemical Support 7
Date published: 2017-03-02
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Rated 5 out of 5 by from FBPase FBPase-1 Inhibitor was reported as a competitive inhibitor at the AMP allosteric binding site of FBPase-1. -SCBT Publication Review
Date published: 2015-05-30
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