FBL3B Antibody (4A1): sc-517115
- FBL3B Antibody (4A1) is a mouse monoclonal IgG2a κ FBL3B antibody provided at 100 µg/ml
- raised against amino acids 167-276 representing partial length FBL3B of human origin
- recommended for detection of FBL3B of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FBL3B Antibody (4A1). This work is in progress.
FBL3B Antibody (4A1) is a mouse monoclonal IgG2a kappa light chain antibody that detects FBL3B protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FBL3B antibody (4A1) is available as the non-conjugated format. FBL3B protein, consisting of 434 amino acids and encoded by the human gene FBXL21, plays a crucial role in cellular processes due to involvement in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex. This complex is essential for substrate recognition and recruitment for ubiquitination, which is a key mechanism for regulating protein degradation. FBL3B contains a 40 amino acid F-box region and three leucine-rich repeats, which are critical for function in targeting various proteins, including cyclins and b-catenin, for proteasomal degradation. FBL3B interaction with Skp1 p19 and CUL-1 highlights importance in the regulation of cell cycle, immune responses, and developmental processes. Additionally, FBL3B is associated with expression and regulation of circadian and cryptochrome proteins, underscoring significance in maintaining cellular rhythms and responses to environmental changes.
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FBL3B Antibody (4A1) References:
- Identification of a family of human F-box proteins. | Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
- A family of mammalian F-box proteins. | Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
- cDNA cloning and expression analysis of new members of the mammalian F-box protein family. | Ilyin, GP., et al. 2000. Genomics. 67: 40-7. PMID: 10945468
- A new subfamily of structurally related human F-box proteins. | Ilyin, GP., et al. 2002. Gene. 296: 11-20. PMID: 12383498
- Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. | Siepka, SM., et al. 2007. Cell. 129: 1011-23. PMID: 17462724
- SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. | Busino, L., et al. 2007. Science. 316: 900-4. PMID: 17463251
- The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. | Winston, JT., et al. 1999. Genes Dev. 13: 270-83. PMID: 9990852
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FBL3B Antibody (4A1) | sc-517115 | 100 µg/ml | $322.00 |